T-cell receptor genes in autoimmune mice: T-cell subsets have unexpected T-cell receptor gene programs.
T-cell receptor genes in autoimmune mice: T-cell subsets have unexpected T-cell receptor gene programs.
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自身免疫小鼠中的 T 细胞受体基因：T 细胞亚群具有意想不到的 T 细胞受体基因程序。
DOI：
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发表时间：
1987
影响因子：
11.1
通讯作者：
M. Greene
中科院分区：
文献类型：
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作者：
Y. Hashimoto;K. Yui;D. Littman;M. Greene
在自身免疫易感性的MRL/MP、lpr/lpr和C3H/HeJ型gld/gld小鼠株中鉴定出两种独特的细胞亚群，它们分别具有Lyt-2-、L3T4-、Thy-1+和Lyt-2-、L3T4-、Ia-、Thy-1-表型。我们现在已经发现这些细胞在其表面表达t细胞受体蛋白。我们的观察结果进一步表明，Thy-1抗原的表达与α链和β链t细胞受体多肽的表达无关。有趣的是，t细胞受体γ链RNA的表达可能影响或与Thy-1分子的表达相关。这些研究表明不同细胞表面结构的不寻常关系可能反映了意想不到的发育程序。
Two unique cell subsets have been identified in the autoimmune-prone MRL/MP lpr/lpr and C3H/HeJ gld/gld murine strains that have the Lyt-2-,L3T4-,Thy-1+, and Lyt-2-,L3T4-,Ia-,Thy-1- phenotypes, respectively. We have now found that these cells express T-cell receptor proteins on their surface. Our observations further indicate that the expression of the Thy-1 antigen does not correlate with the expression of alpha-chain and beta-chain T-cell receptor polypeptides. Interestingly, T-cell receptor gamma-chain RNA expression may be influenced or correlate with Thy-1 molecular expression. These studies indicate unusual relationships of different cell-surface structures that may reflect unexpected developmental programs.