The Spread of an Inversion with Migration and Selection
The Spread of an Inversion with Migration and Selection
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DOI：
10.1534/genetics.117.300426
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发表时间：
2018-01-01
期刊：
影响因子：
3.3
通讯作者：
Barton, Nicholas H.
中科院分区：
文献类型：
--
作者：
Charlesworth, Brian;Barton, Nicholas H.
我们重新检验了柯克帕特里克和巴顿关于倒位扩散到当地人口的模型。该模型假设局部选择维持两个或多个基因座上的等位基因，尽管这些基因座上的替代等位基因从另一个群体中迁入。我们表明，倒位是有利的，因为它阻止了由迁移产生的连锁不平衡的破坏；倒位的选择优势取决于所涉及的基因座之间的重组量，就像在其他情况下，选择倒位是因为它们对重组的影响。我们推导出逆变换的扩散速率的表达式；当逆变换所覆盖的轨迹紧密相连时，这些条件与先前提出的条件有很大偏离，并且意味着逆变换可能只有很小的优势。
We re-examine the model of Kirkpatrick and Barton for the spread of an inversion into a local population. This model assumes that local selection maintains alleles at two or more loci, despite immigration of alternative alleles at these loci from another population. We show that an inversion is favored because it prevents the breakdown of linkage disequilibrium generated by migration; the selective advantage of an inversion is dependent on the amount of recombination between the loci involved, as in other cases where inversions are selected for as a result of their effects on recombination. We derive expressions for the rate of spread of an inversion; when the loci covered by the inversion are tightly linked, these conditions deviate substantially from those proposed previously, and imply that an inversion can then have only a small advantage.