Obstetric outcomes after conservative treatment for intraepithelial or early invasive cervical lesions: systematic review and meta-analysis
Obstetric outcomes after conservative treatment for intraepithelial or early invasive cervical lesions: systematic review and meta-analysis
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DOI：
10.1016/s0140-6736(06)68181-6
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发表时间：
2006-02-11
期刊：
影响因子：
168.9
通讯作者：
Paraskevaidis, E
中科院分区：
文献类型：
--
作者：
Kyrgiou, M;Koliopoulos, G;Paraskevaidis, E
背景 由于有效筛查计划的出现，年轻女性通常使用保守方法治疗宫颈上皮内瘤变和微浸润宫颈癌。在一项荟萃分析中，我们调查了这些程序对随后的生育和妊娠结局的影响。方法我们检索了 MEDLINE 和 EMBASE 中的研究，并根据所使用的保守方法和研究的生育和妊娠结果测量对它们进行分类。使用随机效应模型计算汇总相对风险和 95% CI，并使用 Cochrane 的 Q 检验评估研究间异质性。结果 我们确定了 27 项研究。冷刀锥切术与早产显着相关（
Background Conservative methods to treat cervical intraepithelial neoplasia and microinvasive cervical cancer are commonly used in young women because of the advent of effective screening programmes. In a meta-analysis, we investigated the effect of these procedures on subsequent fertility and pregnancy outcomes.Methods We searched for studies in MEDLINE and EMBASE and classified them by the conservative method used and the outcome measure studied regarding both fertility and pregnancy. Pooled relative risks and 95% CIs were calculated with a random-effects model and interstudy heterogeneity was assessed with Cochrane's Q test.Findings We identified 27 studies. Cold knife conisation was significantly associated with preterm delivery (