Moment-to-Moment BOLD Signal Variability Reflects Regional Changes in Neural Flexibility across the Lifespan
Moment-to-Moment BOLD Signal Variability Reflects Regional Changes in Neural Flexibility across the Lifespan
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DOI：
10.1523/jneurosci.3408-16.2017
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发表时间：
2017-05-31
影响因子：
5.3
通讯作者：
Heller, Aaron S.
中科院分区：
文献类型：
--
作者：
Nomi, Jason S.;Bolt, Taylor S.;Heller, Aaron S.
神经元反应的可变性被认为是灵活和最佳大脑功能的基础。由于之前研究 BOLD 信号变异性的工作是在成人和老年人基于任务的功能磁共振成像环境中进行的，因此目前对人脑在整个生命周期中自发 BOLD 信号变异性的区域变化知之甚少。当前的研究使用了来自大量男性和女性人类参与者样本的静息态 fMRI 数据，涵盖了广泛的年龄范围（6-85 岁），涵盖了两种不同的 fMRI 采集参数（TR = 0.645 和 1.4 s）。包括显着网络关键节点（前岛叶）在内的大脑区域的变异性在整个数据集的生命周期中呈线性增加。相比之下，大多数其他大型网络的变异性在整个生命周期内呈线性下降。这些结果证明了与大脑特定区域相关的 BOLD 变异的独特寿命轨迹，并为越来越多的文献增添了内容，证明了识别功能性大脑成熟的规范轨迹的重要性。
Variability of neuronal responses is thought to underlie flexible and optimal brain function. Because previous work investigating BOLD signal variability has been conducted within task-based fMRI contexts on adults and older individuals, very little is currently known regarding regional changes in spontaneous BOLD signal variability in the human brain across the lifespan. The current study used resting-state fMRI data from a large sample of male and female human participants covering a wide age range (6-85 years) across two different fMRI acquisition parameters (TR = 0.645 and 1.4 s). Variability in brain regions including a key node of the salience network (anterior insula) increased linearly across the lifespan across datasets. In contrast, variability in most other large-scale networks decreased linearly over the lifespan. These results demonstrate unique lifespan trajectories of BOLD variability related to specific regions of the brain and add to a growing literature demonstrating the importance of identifying normative trajectories of functional brain maturation.