RETRACTED ARTICLE: Transurethral ultrasonography-guided injection of adult autologous stem cells versus transurethral endoscopic injection of collagen in treatment of urinary incontinence
RETRACTED ARTICLE: Transurethral ultrasonography-guided injection of adult autologous stem cells versus transurethral endoscopic injection of collagen in treatment of urinary incontinence
复制标题
撤回文章：经尿道超声引导下注射成体自体干细胞与经尿道内窥镜注射胶原蛋白治疗尿失禁的比较
DOI：
10.1007/s00345-007-0190-7
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发表时间：
2007
影响因子：
3.4
通讯作者：
G. Bartsch
中科院分区：
文献类型：
--
作者：
H. Strasser;R. Marksteiner;E. Margreiter;M. Mitterberger;G. Pinggera;F. Frauscher;M. Fussenegger;K. Kofler;G. Bartsch
在过去的几年中，临床前研究为使用成人肌肉来源的干细胞重建下尿路铺平了道路。在2002年9月至2004年10月期间，招募了42名女性和21名男性患有压力性尿失禁（年龄36-84岁），随后通过经尿道超声引导注射从骨骼肌活检获得的自体成肌细胞和成纤维细胞进行治疗。将成纤维细胞注入尿道粘膜下层，而成肌细胞植入横纹括约肌。同时，7名男性和21名女性（年龄39-83岁）也被诊断为压力性尿失禁，采用标准经尿道内窥镜注射胶原蛋白治疗。患者被随机分配到两组。术后随访12个月，39名女性和11名男性在注射自体成肌细胞和成纤维细胞后尿失禁得到治愈。术后平均生活质量评分（术前51.38，术后104.06）、尿道和横纹括约肌厚度（术前2.103 mm，术后3.303 mm）、横纹括约肌收缩力（术前0.56 mm，术后1.462 mm）均有改善。只有两名患者注射胶原蛋白治疗尿失禁治愈。目前的临床结果表明，与注射胶原相比，尿失禁可以通过超声引导注射自体肌和成纤维细胞有效治疗。
In the last years preclinical studies have paved the way for the use of adult muscle derived stem cells for reconstruction of the lower urinary tract. Between September 2002 and October 2004, 42 women and 21 men suffering from urinary stress incontinence (age 36–84 years) were recruited and subsequently treated with transurethral ultrasonography-guided injections of autologous myoblasts and fibroblasts obtained from skeletal muscle biopsies. The fibroblasts were injected into the urethral submucosa, while the myoblasts were implanted into the rhabdosphincter. In parallel, 7 men and 21 women (age 39–83 years) also diagnosed with urinary stress incontinence were treated with standard transurethral endoscopic injections of collagen. Patients were randomly assigned to both groups. After a follow-up of 12 months incontinence was cured in 39 women and 11 men after injection of autologous myoblasts and fibroblasts. Mean quality of life score (51.38 preoperatively, 104.06 postoperatively), thickness of urethra and rhabdosphincter (2.103 mm preoperatively, 3.303 mm postoperatively) as well as contractility of the rhabdosphincter (0.56 mm preoperatively, 1.462 mm postoperatively) were improved postoperatively. Only in two patients treated with injections of collagen incontinence was cured. The present clinical results demonstrate that, in contrast to injections of collagen, urinary incontinence can be treated effectively with ultrasonography-guided injections of autologous myo- and fibroblasts.