HUMAN MALARIA TRANSMISSION STUDIES IN THE ANOPHELES-PUNCTULATUS COMPLEX IN PAPUA-NEW-GUINEA - SPOROZOITE RATES, INOCULATION RATES, AND SPOROZOITE DENSITIES
HUMAN MALARIA TRANSMISSION STUDIES IN THE ANOPHELES-PUNCTULATUS COMPLEX IN PAPUA-NEW-GUINEA - SPOROZOITE RATES, INOCULATION RATES, AND SPOROZOITE DENSITIES
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DOI：
10.4269/ajtmh.1988.39.135
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发表时间：
1988-08-01
影响因子：
3.3
通讯作者：
HEYWOOD, PF
中科院分区：
文献类型：
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作者：
BURKOT, TR;GRAVES, PM;HEYWOOD, PF
在长达 25 个月的时间内，对巴布亚新几内亚马当省 13 个村庄的不同按蚊种类叮咬人类的疟疾子孢子率和接种率进行了测量。点状按蚊复合体的三个成员的分析，65,458 An。法劳蒂, 36,779 安。 koliensis，和 11,667 An。使用基于单克隆抗体的 ELISA 检测登陆渔获物中捕获的点状疟原虫，以检测恶性疟原虫和间日疟原虫的子孢子。 An 中的子孢子率范围为 0-5.5%。法劳蒂，An 中的 0.2%-3.8%。 koliensis，An. 0%-3.3%。标点符号。此外，还有超过 3,000 An。对longirostris进行了分析，在该物种中没有检测到子孢子。在三种媒介物种之间，恶性疟原虫子孢子的密度没有观察到显着差异（几何平均值为 2,320）。然而，按蚊的几何平均间日疟原虫子孢子密度显着更高。 punctulatus (350) 比任一 An. koliensis (160) 或 An.法劳蒂 (150)。一个。 koliensis 比 An. falciparum 或 P. vivax 更不易感染。法劳蒂或安。标点符号。尽管地理上接近，但不同村庄的平均子孢子和接种率存在差异。随着时间的推移，一个村庄内的子孢子和接种率差异很大，但疟疾传播是常年的，在雨季传播率更高。古里安和安.标点符号。
Malaria sporozoite rates and inoculation rates were measured over periods up to 25 months in the different anopheline species biting humans in 13 villages in Madang Province, Papua New Guinea. Analysis of three members of the Anopheles punctulatus complex, 65,458 An. farauti, 36,779 An. koliensis, and 11,667 An. punctulatus caught in landing catches was made using monoclonal antibody based ELISAs to detect sporozoites of Plasmodium falciparum and P. vivax. Sporozoite rates ranged from 0-5.5% in An. farauti, 0.2%-3.8% in An. koliensis, and 0%-3.3% in An. punctulatus. In addition, over 3,000 An. longirostris were analyzed and sporozoites were not detected in this species. No significant differences were observed between the three vector species in the densities of P. falciparum sporozoites (geometric mean 2,320). However, the geometric mean P. vivax sporozoite density was significantly higher in An. punctulatus (350) than in either An. koliensis (160) or An. farauti (150). An. koliensis was less susceptible to infections of P. falciparum or P. vivax than either An. farauti or An. punctulatus. Variations in average sporozoite and inoculation rates were found among different villages, despite their close geographic proximity. Sporozoite and inoculation rates varied greatly within a village over time, but malaria transmission was perennial with a higher transmission during the wet season by An. koliensis and An. punctulatus.