Innate Lymphoid Cells: A Promising New Regulator in Fibrotic Diseases
Innate Lymphoid Cells: A Promising New Regulator in Fibrotic Diseases
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DOI：
10.3109/08830185.2015.1068304
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发表时间：
2016-09
影响因子：
5
通讯作者：
Yi Zhang;Jun Tang;Z. Tian;J. V. van Velkinburgh;Jianxun Song;Yuzhang Wu;B. Ni
中科院分区：
文献类型：
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作者：
Yi Zhang;Jun Tang;Z. Tian;J. V. van Velkinburgh;Jianxun Song;Yuzhang Wu;B. Ni
纤维化是慢性炎症和细胞外基质持续堆积的结果，组织损伤和修复的循环成为主要特征。先天性免疫系统和获得性免疫系统在纤维化的发展过程中都起着关键作用。新近发现的天然淋巴样细胞亚群主要定位于上皮细胞表面，被认为是慢性炎症和组织重塑的调节因子，是天然免疫和获得性免疫之间的功能桥梁。此外，最近的研究表明，ILC是几种纤维化疾病的潜在促成因素，如肝纤维化和肺纤维化。在这里，我们将总结和讨论ILCs及其相关因素在纤维化疾病中的关键作用及其移植到临床的潜力。
Fibrosis is a consequence of chronic inflammation and the persistent accumulation of extracellular matrix, for which the cycle of tissue injury and repair becomes a predominant feature. Both the innate and adaptive immune systems play key roles in the progress of fibrosis. The recently identified subsets of innate lymphoid cells (ILCs), which are mainly localize to epithelial surfaces, have been characterized as regulators of chronic inflammation and tissue remodeling, representing a functional bridge between the innate and adaptive immunity. Moreover, recent research has implicated ILCs as potential contributing factors to several kinds of fibrosis diseases, such as hepatic fibrosis and pulmonary fibrosis. Here, we will summarize and discuss the key roles of ILCs and their related factors in fibrotic diseases and their potential for translation to the clinic.