ROR1C Regulates Differentiation of Myeloid-Derived Suppressor Cells.
ROR1C Regulates Differentiation of Myeloid-Derived Suppressor Cells.
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DOI：
10.1016/j.ccell.2015.07.007
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发表时间：
2015-08-10
期刊：
影响因子：
50.3
通讯作者：
Nefedova Y
中科院分区：
文献类型：
--
作者：
Gabrilovich D;Nefedova Y
骨髓源性抑制细胞（MDSC）在癌症中起主要作用。MDSC扩增与肿瘤进展密切相关，但这种扩增的分子机制仍知之甚少。在这一期的《癌细胞》中，Strauss及其同事描述了核受体ROR1C在MDSC分化和扩增调控中的作用。
Myeloid-derived suppressor cells (MDSCs) play a major role in cancer. MDSC expansion is closely associated with tumor progression, but molecular mechanisms of this expansion remain poorly understood. In this issue of Cancer Cell, Strauss and colleagues describe the roles of the nuclear receptor ROR1C in the regulation of MDSC differentiation and expansion.