Venous thromboembolism in critically ill children.
Venous thromboembolism in critically ill children.
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DOI：
10.1097/mop.0000000000000084
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发表时间：
2014-06
影响因子：
3.6
通讯作者：
Faustino EV
中科院分区：
文献类型：
--
作者：
Polikoff LA;Faustino EV
回顾目前关于危重儿童静脉血栓栓塞的文献 人们越来越关注危重儿童的静脉血栓栓塞及其并发症。由于正在接受的治疗及其基础状况，危重儿童发生血栓栓塞的风险增加。血栓形成和感染之间存在着复杂的关系。血栓是感染的病灶，而感染会增加血栓形成的风险。缺乏预防和治疗血栓栓塞的儿科具体指南。目前的指南基于成人的数据。新型抗凝剂现已可用于成人。正在进行研究以确定其对儿童的安全性。最近开发了风险评估工具来确定危重儿童的血栓栓塞风险。某些分子与成人血栓栓塞有关。儿科重症监护人员应认识到危重儿童静脉血栓栓塞的重要性，以便及早识别和治疗。迫切需要足够有力的临床试验来产生证据来指导危重儿童血栓栓塞的治疗和预防。包含生物标志物的风险评估工具可以提高我们预测危重儿童血栓栓塞发生的能力。
To review the current literature on venous thromboembolism in critically ill children There is increasing concern for venous thromboembolism and its complications in critically ill children. Critically ill children are at increased risk of thromboembolism because of the treatment that they are receiving and their underlying condition. A complex relationship exists between thrombosis and infection. A thrombus is a nidus for infection while infection increases the risk of thrombosis. Pediatric-specific guidelines for the prevention and treatment of thromboembolism are lacking. Current guidelines are based on data from adults. Novel anticoagulants are now available for use in adults. Studies are ongoing to determine their safety in children. Risk assessment tools have recently been developed to determine the risk of thromboembolism in critically ill children. Certain molecules are associated with thromboembolism in adults. Pediatric critical care practitioners should be cognizant of the importance of venous thromboembolism in critically ill children to allow for early identification and treatment. Adequately powered clinical trials are critically needed to generate evidence that will guide the treatment and prevention of thromboembolism in critically ill children. Risk assessment tools that incorporate biomarkers may improve our ability to predict the occurrence of thromboembolism in critically ill children.