RELATIONSHIP BETWEEN AGE AND PLASMA T-PA, PA-INHIBITOR, AND PA ACTIVITY
RELATIONSHIP BETWEEN AGE AND PLASMA T-PA, PA-INHIBITOR, AND PA ACTIVITY
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DOI：
10.1016/0049-3848(87)90264-7
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发表时间：
1987-06-01
影响因子：
7.5
通讯作者：
TAKADA, A
中科院分区：
文献类型：
--
作者：
HASHIMOTO, Y;KOBAYASHI, A;TAKADA, A
年龄与血栓形成的发生呈正相关。我们研究了年龄与纤溶活性之间的关系，即组织纤溶酶原激活物（t-PA）抗原，纤溶酶原激活物抑制剂（PA抑制剂）活性和纤溶酶原激活物活性（PA活性）水平。随着年龄的增长，t-PA抗原和PA抑制剂的显着增加。PA活性随年龄增长而下降。提示PA活性随年龄增长而降低的趋势可能与老年人血栓形成的高发病率有关。
A positive correlation between age and the occurrence of thrombosis has been suggested. We studied the relationship between age and fibrinolytic activities; namely levels of tissue plasminogen activator (t-PA) antigen, plasminogen activator inhibitor (PA inhibitor) acivity, and plasminogen activator activity (PA activity). A dramatic increase in both t-PA antigen and PA inhibitor was shown in persons with increasing age. PA activity decreased with age. Therefore it is suggested that the tendency of decreased PA activity with increasing age may be related to the high incidence of thrombosis in older persons.