Validation of pretreatment neutrophil-lymphocyte ratio as a prognostic factor in a European cohort of patients with upper tract urothelial carcinoma
Validation of pretreatment neutrophil-lymphocyte ratio as a prognostic factor in a European cohort of patients with upper tract urothelial carcinoma
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DOI：
10.1111/bju.12441
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发表时间：
2014-09-01
影响因子：
4.5
通讯作者：
Hutterer, Georg C.
中科院分区：
文献类型：
--
作者：
Dalpiaz, Orietta;Ehrlich, Georg C.;Hutterer, Georg C.
目的探讨中性粒细胞-淋巴细胞比值 (NLR) 在欧洲上尿路尿路上皮细胞癌 (UUT-UCC) 患者大型队列中的潜在预后意义。 患者和方法我们回顾性评估了 202 名连续的非转移性上尿路尿路上皮细胞癌 (UUT-UCC) 患者的数据，这些患者接受了 1990 年至 2012 年间在单一三级学术中心进行的手术。使用 Kaplan-Meier 方法评估患者的癌症特异性生存期 (CSS) 和总生存期 (OS)。为了评估 NLR 的独立预后意义，对两个终点应用多变量比例 Cox 回归模型。结果较高的 NLR 与较短的 CSS 显着相关（P = 0.002， 对数秩检验），以及较短的 OS（P < 0.001，对数秩检验）。多变量分析确定高 NLR 作为患者 CSS（风险比 2.72，95% CI 1.25-5.93，P = 0.012）和 OS（风险比 2.48，95% CI 1.31-4.70，P = 0.005）。结论在本队列中，与术前 NLR 较低的患者相比，术前 NLR 较高的患者在 UUT-UCC 根治手术后具有较高的癌症特异性死亡率和总体死亡率。这种易于识别的实验室测量结果应被视为未来 UUT-UCC 的额外预后因素。
ObjectiveTo investigate the potential prognostic significance of the neutrophil-lymphocyte ratio (NLR) in a large European cohort of patients with upper urinary tract urothelial cell carcinoma (UUT-UCC).Patients and MethodsWe retrospectively evaluated data from 202 consecutive patients with non-metastatic upper urinary tract urothelial cell carcinoma (UUT-UCC), who underwent surgery between 1990 and 2012 at a single tertiary academic centre.Patients' cancer-specific survival (CSS) and overall survival (OS) were assessed using the Kaplan-Meier method.To evaluate the independent prognostic significance of the NLR, multivariate proportional Cox regression models were applied for both endpoints.ResultsA higher NLR was significantly associated with shorter CSS (P = 0.002, log-rank test), as well as with shorter OS (P < 0.001, log-rank test).Multivariate analysis identified a high NLR as an independent prognostic factor for patients' CSS (hazard ratio 2.72, 95% CI 1.25-5.93, P = 0.012), and OS (hazard ratio 2.48, 95% CI 1.31-4.70, P = 0.005).ConclusionsIn the present cohort, patients with a high preoperative NLR had higher cancer-specific and overall mortality after radical surgery for UUT-UCC, compared with those with a low preoperative NLR.This easily identifiable laboratory measure should be considered as an additional prognostic factor in UUT-UCC in future.