Prognostic significance of high serum p53 antibody titers in patients with esophageal squamous cell carcinoma
Prognostic significance of high serum p53 antibody titers in patients with esophageal squamous cell carcinoma
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DOI：
10.1007/s10388-018-0629-5
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发表时间：
2018-10-01
期刊：
影响因子：
2.4
通讯作者：
Shimada, Hideaki
中科院分区：
文献类型：
--
作者：
Suzuki, Takashi;Yajima, Satoshi;Shimada, Hideaki
背景：P53蛋白的过度表达通常是由基因改变引起的，据报道可诱导血清中产生抗P53抗体。然而，围术期血清P53抗体(S-P53-Abs)滴度对食管鳞癌患者预后的影响鲜有报道。其中58例接受了5-FU和顺铂的新辅助化疗。1.3U/ml的临界值表示血清阳性患者，13.4U/ml的临界值表示高滴度患者。结果治疗前S-P53抗体阳性29例(21.5%)。血清阳性患者和高滴度患者(>；13.4U/ml)的频率与肿瘤进展没有显著相关性。在多变量分析的基础上，血清阳性患者的总体存活率并不显著差，而高滴度患者的总体存活率显著差(P<；0.001)。此外，S-P53-Abs滴度与新辅助化疗的疗效无关。在血清阳性患者中，S-P53-Abs阴转者更有可能获得长期生存。结论本研究确定S-P53-Abs的高滴度是降低食道癌患者总生存期的独立危险因素。S-P53-Abs阴转者预后良好。
Background The p53 protein overexpression that usually results from genetic alterations reportedly induces serum antibodies against p53. However, little information is available about the prognostic significance of perioperative serum p53 antibody (s-p53-Abs) titers in patients with esophageal squamous cell carcinoma.Methods In this study, we retrospectively evaluated the clinical significance of perioperative s-p53-Abs in 135 patients with esophageal squamous cell carcinoma. Of these, 58 patients received neoadjuvant chemotherapy comprising 5-FU and CDDP. While the cutoff level at 1.3 U/ml indicated seropositive patients, level of 13.4 U/ml was used to identify high-titer patients. We monitored serum titers seropositive patients after surgery and evaluated the prognostic significance by the univariate and multivariate analyses.Results In this study, 29 patients (21.5%) were positive for s-p53-Abs before treatment. The frequency of both seropositive patients and high-titer patients (> 13.4 U/ml) was not significantly associated with tumor progression. While seropositive patients did not demonstrate significant poor overall survival, high-titer patients demonstrated significant poor overall survival based on the multivariate analysis (P < 0.001). Moreover, the s-p53-Abs titer did not correlate with the response to neoadjuvant chemotherapy. Among seropositive patients, the negative conversion of s-p53-Abs more likely led to be long-term survival.Conclusions This study determined that the high-titer of s-p53-Abs was an independent risk factor to reduce the overall survival of patients with esophageal cancer patients. The negative conversion of s-p53-Abs could be a good indicator of favorable prognosis.