Positional changes of the ocular organs during craniofacial development
Positional changes of the ocular organs during craniofacial development
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颅面发育过程中眼器官的位置变化
DOI：
10.1002/ar.23588
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发表时间：
2017
影响因子：
--
通讯作者：
Takakuwa T
中科院分区：
文献类型：
--
作者：
Osaka M;Ishikawa A;Yamada S;Uwabe C;Imai H;Matsuda T;Yoneyama A;Takeda T;Takakuwa T
本研究旨在描述颅面发育过程中眼器官的位置变化，并探讨眼器官与其他内部结构之间的关系。为此，我们使用高分辨率磁共振成像和相位对比X射线计算机断层扫描追踪了56例处于不同发育阶段的人类早期胎儿样本中眼部器官的位置。在Carnegie阶段（CS）16，眼睛位于腹侧视图中的外侧，然后在发育过程中改变其位置向内侧。眼睛一直留在脑颅中，直到CS 17。然而，在CS 18之后，眼睛改变了它们在脏颅中的中间和尾部位置。侧位片上眼与垂体的位置关系随发育的进行而改变。具体来说，它们在CS 17时彼此接近，但在发展的后期阶段分开了。这些位置的变化也证明了定量与形态分析。根据目前的数据，眼睛的位置变化可以分为以下阶段：阶段1，剧烈的位置变化（早期胎儿期至CS23）;阶段2，轻度位置变化（稳定; CS23后的早期胎儿期）。值得注意的是，在本研究中测量的所有绝对长度都随着顶臀长度的增加而线性增加，而与相位无关，而测量的角度和比率的特征在相位1和2中有差异地变化。本研究结果有助于提高对眼器官和颅面区正常和异常发育的认识。Anat Rec，300：2107-2114，2017。© 2017 Wiley Periodicals，Inc.
The present study aimed to describe the positional changes of the ocular organs during craniofacial development; moreover, we examined the relationships among the ocular organs and other internal structures. To do this, we traced the positions of the ocular organs in 56 human early fetal samples at different stages of development using high‐resolution magnetic resonance imaging and phase‐contrast X‐ray computed tomography. The eyes were located on the lateral side in the ventral view at Carnegie stage (CS) 16, and then changed their positions medially during development. The eyes remained in the neurocranium until CS17. However, the eyes changed their positions medially and caudally in the viscerocranium after CS18. The positional relationship between the eyes and pituitary gland changed in the lateral view as development progressed. Specifically, they were close to each other at CS17, but moved apart during the later stages of development. These positional changes were also demonstrated quantitatively with morphometric analyses. Based on the present data, the positional changes of the eyes can be categorized into phases, as follows: Phase 1, dramatic positional changes (early fetal period until CS23); and Phase 2, mild positional changes (stabilized; early fetal period after CS23). Notably, all absolute lengths measured in the present study linearly increased as the crown‐rump length increased irrespective of the phase, while features of the measured angles and ratios differentially changed in Phases 1 and 2. The present data may help improve our understanding of both the normal and abnormal development of the ocular organs and craniofacial area. Anat Rec, 300:2107–2114, 2017. © 2017 Wiley Periodicals, Inc.