Soluble thrombomodulin concentration is raised in scleroderma associated pulmonary hypertension
Soluble thrombomodulin concentration is raised in scleroderma associated pulmonary hypertension
复制标题
硬皮病相关肺动脉高压中可溶性血栓调节蛋白浓度升高
DOI：
10.1136/ard.59.2.132
复制
发表时间：
2000
影响因子：
27.4
通讯作者：
C. Black
中科院分区：
文献类型：
--
作者：
R. Stratton;Lucie Pompon;J. G. Coghlan;J. Pearson;C. Black
目的探讨血栓调节蛋白在硬皮病相关性肺动脉高压中的表达。方法测定34例超声心动图显示为肺动脉高压的硬皮病患者血浆样品中的可溶性血栓调节素（sTM），并与38例硬皮病对照患者和20例健康对照患者的血浆样品进行比较。我们对34例硬皮病相关性肺动脉高压患者进行了一系列的sTM测量，以研究sTM浓度随病情进展可能发生的变化。结果硬皮病相关性肺动脉高压患者的平均sTM与硬皮病对照组相比（平均sTM 65.4 ng/mlv 43.3 ng/ml, p<0.05）和健康对照组相比（平均sTM 38.1 ng/ml, p<0.05）均升高。硬皮病对照组和健康对照组的平均sTM无显著差异。平均sTM浓度不随肺动脉高压的进展而改变。结论硬皮病相关性肺动脉高压患者血浆sTM升高。硬皮病相关肺动脉高压的发病机制可能不同于其他形式的肺血管疾病的发病机制。
OBJECTIVE To investigate the expression of thrombomodulin in scleroderma associated pulmonary hypertension. METHODS Soluble thrombomodulin (sTM), was measured in plasma samples from 34 scleroderma patients shown to have pulmonary hypertension at echocardiogram, and comparison drawn against samples from 38 scleroderma control patients, and 20 healthy controls. Serial measurements of sTM were performed in the 34 patients with scleroderma associated pulmonary hypertension to investigate possible changes in sTM concentration with progression of the condition. RESULTS Mean sTM was raised in scleroderma associated pulmonary hypertension when compared with scleroderma controls (mean sTM 65.4 ng/mlv 43.3 ng/ml, p<0.05), and when compared with healthy controls (mean sTM 38.1 ng/ml, p<0.05). There was no significant difference between mean sTM in scleroderma controls and healthy controls. Mean sTM concentration did not change with progression of pulmonary hypertension. CONCLUSION Plasma sTM is raised in scleroderma associated pulmonary hypertension. The pathogenesis of scleroderma associated pulmonary hypertension may be distinct from the pathogenesis of other forms of pulmonary vascular disease.