Stroke in black south African HIV-positive patients - A prospective analysis
Stroke in black south African HIV-positive patients - A prospective analysis
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DOI：
10.1161/01.str.0000043821.35051.fa
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发表时间：
2003-01-01
期刊：
影响因子：
8.3
通讯作者：
Modi, G
中科院分区：
文献类型：
--
作者：
Mochan, A;Modi, M;Modi, G
背景和目的——与 HIV 感染相关的中风的特征尚不清楚。在这项研究中，我们分析了非洲黑人人群中的相关性。方法——对 35 名住院的南非黑人异性恋 HIV 感染患者的临床、实验室和放射学特征进行前瞻性研究，这些患者没有滥用静脉注射药物并出现中风。这些患者未接受过抗逆转录病毒治疗。患有其他颅内占位性病变的患者被排除在研究之外。结果-年龄范围为20至61岁（平均32.1岁）。其中女性21例，男性14例，男女比例为1.5：1。 3 例（94%）发生脑梗死，2 例（6%）发生脑出血。 35 名患者中的 30 名 (86%) 被确定为潜在原因，包括凝血病、脑膜炎、心源性栓塞和高血压。最常见的凝血病是蛋白质 S 缺乏。 5 名患者 (14%) 未发现病因。结论 - 结果与针对 HIV 阴性的年轻非洲黑人中风患者的研究数据相似。
Background and Purpose-Stroke associated with HIV infection is poorly characterized. In this study we analyze the association in a black African population.Methods-The clinical, laboratory, and radiological characteristics of 35 hospital-based black South African, heterosexual, HIV-infected patients who did not abuse intravenous drugs and presented with strokes were prospectively studied. The patients were antiretroviral therapy naive. Patients with other intracranial space-occupying lesions were excluded from the study.Results-The age range was 20 to 61 years (mean, 32.1 years). There were 21 female and 14 male patients, with a female to male ratio of 1.5:1. Cerebral infarction occurred in 3 3 patients (94%) and intracerebral hemorrhage in 2 patients (6%). Underlying causes were identified in 30 of the 35 patients (86%) and included coagulopathies, meningitis, cardioembolism, and hypertension. The most common coagulopathy was protein S deficiency. No cause was found in 5 patients (14%).Conclusions-The results are similar to data from studies on young black African stroke patients who are HIV negative.