Inheritance and developmental pattern of cerebral hernia in the crested Polish chicken
Inheritance and developmental pattern of cerebral hernia in the crested Polish chicken
复制标题
波兰凤头鸡脑疝的遗传及发育规律
DOI：
10.1002/jez.b.22464
复制
发表时间：
2012
期刊：
影响因子：
--
通讯作者：
Saito N
中科院分区：
文献类型：
--
作者：
Yoshimura K;Kinoshita K;Mizutani M;Matsuda Y;Saito N
一些凤头鸡品种，如波兰鸡，在其头骨的前背区域显示出骨质突起。他们的大脑形状显示出解剖学上的特殊性，其特征是大脑半球的上推，称为“脑疝”。一些早期的工作表明，这种表型可能是由遗传因素和任何影响大脑和/或头骨发育的修饰剂引起的。然而，致病基因及其形成机制仍不清楚。本研究的目的是分析脑疝的遗传和个体发生过程中的冠波兰鸡。首先，我们用波兰鸡和PNP近交系构建了资源家系。对该家系的遗传学分析表明脑疝受一个常染色体隐性单基因控制，并与嵴形成密切相关。此外，我们对后代脑结构的形态学分析表明，在胚胎后期，特别是在孵化15天后，脑腔的显着扩大，可能是脑疝的主要原因。J. Exp. Zool.（Mol. Dev. Evol.）9999B：613-620，2012.© 2012 Wiley Periodicals，Inc.
A number of crested chicken strains, such as the Polish chicken, exhibit a bony protuberance in the anterodorsal region of their skulls. The shape of their brain shows the anatomical peculiarity that is characterized by the upthrusting of cerebral hemispheres, called “cerebral hernia.” Some early works suggested that this phenotype may be caused by a genetic factor and any modifiers influencing the development of brain and/or skull. However, the causative gene and its formation mechanism are still unclear. The present study is aimed to analyze the inheritance and ontogenic process of cerebral hernia in the crested Polish chicken. Firstly, we constructed the resource family with the Polish chicken and PNP inbred strain. Genetic analysis of this family revealed that cerebral hernia is controlled by a single autosomal recessive gene and is closely associated with crest formation. Furthermore, our morphological analysis of brain structures in the progenies suggested that the significant enlargement of brain cavity at later stages of embryos, particularly after 15 days of incubation, may be the main cause of cerebral hernia. J. Exp. Zool. (Mol. Dev. Evol.) 9999B:613–620, 2012. © 2012 Wiley Periodicals, Inc.