Is Graphene a Promising Nano-Material or Scaffold Materials in Neural Tissue Regeneration?
Is Graphene a Promising Nano-Material or Scaffold Materials in Neural Tissue Regeneration?
复制标题
石墨烯是神经组织再生中有前途的纳米材料或支架材料吗？
DOI：
10.1166/jbt.2018.1829
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发表时间：
2018
影响因子：
0.1
通讯作者：
Fan Yubo
中科院分区：
文献类型：
--
作者：
Yu Haoran;Ding Xili;Liu Haifeng;Fan Yubo
石墨烯出色的内在特性推动了再生医学的进一步研究和开发，这一点已被越来越多的文章所证实。石墨烯独特的电学性质可能为神经组织再生提供了一个有意义的途径，因为神经系统的功能依赖于电活动，以及神经细胞。本文综述了石墨烯基材料的最新进展及其在神经组织再生中的潜在应用。本文就神经再生的机制和治疗方法作一综述。介绍了石墨烯的力学性能和电学性能的研究进展。特别是，我们专注于石墨烯基材料用于神经组织再生的体外研究，包括在各种刺激下的条件下或没有。此外，强调了石墨烯基材料在动物模型中的评价。基于这些先进的研究，我们对石墨烯基材料在神经组织再生中的应用有了全面的认识。在结论中还讨论了未来的前景。
The outstanding intrinsic properties of graphene have boosted further research and development for regenerative medicine as confirmed by the increasing number of articles in the topic. The unique electrical properties of graphene may provide a meaning access for neural tissue regeneration since the functions of nervous system depend on electrical activities, as well as the neural cells. Herein, a thorough account of the latest progress in graphene-based materials and their latent applications for neural tissue regeneration are given. In this review, the mechanism of nerve regeneration and a review of therapy methods are presented. Recent progresses mostly focusing on the mechanical and electrical properties of graphene are described. In particular, we focus on the in vitro studies of graphene-based materials used for neural tissue regeneration, including the conditions under various stimulations or not. Moreover, the evaluations of graphene-based materials in animal models are highlighted. Based on these advanced studies, we have gained a holistic vision of graphene-based materials application in neural tissue regeneration. Future perspectives are also addressed in the conclusion.