Toxoplasmic encephalomyelitis VI Clinical diagnosis of infantile or congenital toxoplasmosis, survival beyond infancy
Toxoplasmic encephalomyelitis VI Clinical diagnosis of infantile or congenital toxoplasmosis, survival beyond infancy
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DOI：
10.1001/archneurpsyc.1942.02290110009001
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发表时间：
1942-11-01
影响因子：
--
通讯作者：
Paige, BH
中科院分区：
文献类型：
--
作者：
Cowen, D;Wolf, A;Paige, BH
本文报告9例婴儿或先天性弓形虫脑脊髓炎的临床观察。患者在婴儿期死于感染的急性或亚急性期。突出的是在出生时或出生后不久发生眼部病变和神经系统症状和体征。X线片显示脑内多发性钙化灶。还报告了前6例临床确诊病例。大多数是婴儿期存活的儿童，表明慢性、治愈或潜伏感染。在这个阶段，突出的症状通常是视力下降，这是由已愈合的局灶性脉络膜视网膜炎引起的，很容易通过眼底镜识别。斜视，小眼球和轻微的先天性眼部缺陷也可能存在。全身抽搐或神经系统症状持续存在或稍后出现。在大多数（如果不是全部的话）这些患者中，子宫内开始的疾病是有压力的。目前的迹象表明，这种寄生虫感染是广泛传播的，在美国。S.在S.美国和欧洲也是。各种哺乳动物，也许还有鸟类，可能是动物宿主，但传播给人类的方式尚不清楚。本文对弓形虫病血清中和试验技术作了较详细的描述和讨论。
Clinical observations on 9 cases of infantile, or congenital, toxoplasmic encephalomyelitis, recognized at necropsy, are reported. The patients died during infancy in the acute or subacute stage of the infection. Outstanding was the occurrence at or soon after birth of ocular lesions and neurologic symptoms and signs. Multiple foci of intracerebral calcification were demonstrated by x-ray. Also reported are the first 6 clinically identified cases. The majority are children who have survived infancy, indicating chronic, healed or latent infection. In.this stage the outstanding symptom is usually diminution in vision, resulting from healed focal chorioretinitis, readily identifiable ophthalmo-scopically. Strabismus, microphthalmos and minor congenital ocular defects may be present also. Generalized convulsions or neurological symptoms persist or appear later. The intrauterine inception of the disease in most, if not all, of these patients is stressed. The present indications are that this parasitic infection is widely disseminated in the U. S. Cases have been encountered in S. America and Europe as well. Various mammals, and perhaps birds, are probably the animal reservoirs, but the mode of transmission to man is not yet known. A detailed description and discussion of the technic of a serum neutralization test for toxoplasmosis are given.