Phloroglucinol derivatives from Hypericum japonicum
Phloroglucinol derivatives from Hypericum japonicum
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DOI：
10.1016/s0031-9422(00)94784-8
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发表时间：
1994-01-01
期刊：
影响因子：
--
通讯作者：
Isoi, Koichiro
中科院分区：
文献类型：
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作者：
Ishiguro, Kyoko;Nagata, Satoko;Isoi, Koichiro
在生物活性引导下，对日本金丝桃（Hypericum japonicum）全株甲醇和醚提取物进行了分离，得到了两个新的间苯三酚衍生物。sarothralen C和sarothralen d结构是阐明2 -((3、5、7-dihydroxy-8 - (2-methyl-1-oxopropyl) 2-methyl-2 - (4-methy1-3-pentenyl) 6-chromanyl)甲基)3,5-dihydroxy-6——(2-methyl-1-oxopropyl) 4, 4-dimethyl-2, 5-cyclohexadien-1-one和2 -((3、5、7-dihydroxy-6 - (2-methyl-1-oxopropyl) 2-methyl-2 - (4-methyl-3-pentenyl) 8-chromanyl)甲基)3,5-dihydroxy-6——(2-methyl-1-oxopropyl) 4, 4-dimethyl-2 5-cyclohexadien-1-one,分别通过光谱方法。这些化合物对金黄色葡萄球菌具有抗菌活性。
Bioactivity guided fractionation of the methanol and ether extracts of the whole plants of Hypericum japonicum has afforded two new phloroglucinol derivatives, sarothralen C and sarothralen D. Their structures were elucidated as 2-((3,5,7-dihydroxy-8-(2-methyl-1-oxopropyl)-2-methyl-2-(4-methy1-3-pentenyl)-6-chromanyl) methyl)-3,5-dihydroxy-6-(2-methyl-1-oxopropyl)-4,4-dimethyl-2,5-cyclohexadien-1-one and 2-((3,5,7-dihydroxy-6-(2-methyl-1-oxopropyl)-2-methyl-2-(4-methyl-3-pentenyl)-8-chromanyl) methyl)-3,5-dihydroxy-6-(2-methyl-1-oxopropyl)-4,4-dimethyl-2,5-cyclohexadien-1-one, respectively, by spectral methods. These compounds possess antimicrobial activity against Staphylococcus aureus.