Cytokine levels and pathological characteristics of a patient with severe coronavirus disease 2019: a case report.
Cytokine levels and pathological characteristics of a patient with severe coronavirus disease 2019: a case report.
复制标题
2019年重症冠状病毒病患者细胞因子水平及病理特征：一例报告
DOI：
10.1097/cm9.0000000000001540
复制
发表时间：
2022-01-05
影响因子：
6.1
通讯作者：
Yu K
中科院分区：
文献类型：
--
作者：
Kang K;Gao Y;Zhao M;Fei D;Ye M;Gao Y;Yang W;Wang C;Liu H;Chang G;Kang X;Luo Y;Du X;Qi J;Tian L;Zhou M;Hao C;Yu K
致编辑：2019冠状病毒病（COVID-19）的临床谱似乎很广，从无症状到严重进行性肺炎伴呼吸衰竭、多器官衰竭，甚至死亡。在这里，我们调查了一名死于严重COVID-19的患者的临床和病理特征。我们的发现将有助于更深入地了解COVID-19的发病机制和进展，并改善临床策略以对抗疾病。2020年1月23日，一名57岁的男性无相关病史，在参加家庭聚会后2天出现疲劳和发热。在家庭聚会的成员中，有一位亲戚从武汉来。9天后，患者出现发热和咳嗽，并前往急诊室就诊。咽拭子在实时逆转录聚合酶链反应中对严重急性呼吸综合征冠状病毒2（SARS-COV-2）呈阳性。他住进当地医院，接受支持性治疗、抗病毒药物、干扰素-g雾化吸入和氧气治疗。2月8日，咳嗽、发热和呼吸困难进一步发展。他接受了无创机械通气治疗。2月18日，他因呼吸急促转入上级医院。他的氧合指数降至85.8 mmHg，并开始有创通气。综合治疗措施包括抗生素
To the Editor: The clinical spectrum of coronavirus disease 2019 (COVID-19) appears to be wide, ranging from asymptomatic to severe progressive pneumonia with respiratory failure, multiorgan failure, and even death. Here, we investigated the clinical and pathological characteristics of a patient who died from severe COVID-19. Our findings will facilitate a deeper understanding of the pathogenesis and progression of COVID-19 and improve clinical strategies to combat the disease.On January 23, 2020, a 57-year-old man without relevant history presented with fatigue and fever after attending a family party 2 days prior. Among the members of the family party, one relative had traveled from Wuhan. Over 9 days, the fever and cough developed, and the patient visited the emergency department. A throat swab was positive for severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) on real-time reverse-transcription polymerase chain reaction. He was admitted to the local hospital and received supportive therapies, anti-viral agents, atomized inhalation of interferon-g, and oxygen therapy. Cough, fever, and dyspnea further developed on February 8. He received non-invasive mechanical ventilation therapy. On February 18, he was transferred to a superior hospital with shortness of breath. His oxygenation index decreased to 85.8 mmHg, and invasive ventilation was initiated. Comprehensive treatment measures included antibiotic