A Microbe-Dependent Viral Key to Crohn's Box
A Microbe-Dependent Viral Key to Crohn's Box
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DOI：
10.1126/scitranslmed.3001422
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发表时间：
2010-08-04
影响因子：
17.1
通讯作者：
Turnbaugh, Peter J.
中科院分区：
文献类型：
--
作者：
Peterson, Daniel A.;Turnbaugh, Peter J.
一旦潘多拉打开了她的命运之盒，释放了里面的邪恶力量，就不可能把它们放回去了。现在，关于克罗恩病的新研究表明，存在一种病毒“钥匙”，它可以不可逆地使基因易感的小鼠容易发病。事实上，宿主基因型、病毒感染、肠道损伤和数万亿肠道微生物之间的危险联系可能在一定程度上决定了哪些个体发展为全面疾病状态。这些发现表明，病毒和细菌触发可能作为克罗恩病的治疗靶点，并提出了与炎症、宿主免疫状态、微生物群落结构和人类健康有关的新假设。
Once Pandora unlocked her fateful box and liberated the evil forces within, it became impossible to put them back. Now, new work on Crohn's disease suggests the existence of a viral "key" that irreversibly renders a genetically susceptible mouse prone to pathogenesis. Indeed, dangerous liaisons among host genotype, viral infection, intestinal injury, and trillions of gut microbes may in part determine which individuals progress to a full-blown disease state. These findings suggest that viral and bacterial triggers may serve as therapeutic targets for Crohn's and prompt new hypotheses that relate inflammation, host immune status, microbial community structure, and human health.