Neurodevelopmental Outcomes of Twins Compared With Singleton Children: A Systematic Review.
Neurodevelopmental Outcomes of Twins Compared With Singleton Children: A Systematic Review.
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DOI：
10.1017/thg.2018.3
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发表时间：
2018-04
期刊：
影响因子：
--
通讯作者：
Adebamowo CA
中科院分区：
文献类型：
--
作者：
Babatunde OA;Adebamowo SN;Ajayi IO;Adebamowo CA
超过2亿5岁以下的儿童未能充分发挥其认知潜力，双胞胎儿童尤其面临风险。在这篇文章中，我们回顾了研究双胞胎与单胞胎相比，在神经发育结果的差异。我们检索了Medline数据库中关于双胞胎、单胞胎、神经和认知发育的文章。我们还检查了相关出版物的参考书目，以识别2011年至2017年的相关文章。我们的检索标准得到了162项研究，其中8项符合纳入标准。在检查的8项研究中，4项是前瞻性随访研究，3项是横断面研究，1项是随机对照试验。其中五项研究是在发达国家进行的，他们发现双胞胎和单胞胎之间的神经发育结果没有统计学上的显著差异。然而，在发展中国家进行的三项研究中，有两项发现了一种差异，即单身子女的学业成绩明显高于双胞胎。在生命早期（1-5岁）测量神经发育结果的研究显示，双胞胎与单胞胎之间没有显着差异，而在生命后期测量的研究则显示出双胞胎与单胞胎之间的混合差异。总的来说，这些研究可能不够有力，可能没有得到最佳的设计和实施。需要有足够的样本量，良好的设计和所有相关协变量的最佳测量的研究，以解决文献中相互矛盾的报告。
More than 200 million children aged <5 years fail to reach their full cognitive potential, and children born as twins are particularly at risk. In this article, we review studies that examined differences in the neurodevelopmental outcomes of twins compared to singletons. We searched the Medline database for articles on twins, singletons, neuro, and cognitive development. We also inspected bibliographies of relevant publications to identify related articles from 2011 to 2017. Our search criteria yielded 162 studies, 8 of which met the inclusion criteria. Of the eight studies examined, four were prospective follow-up studies, three were cross-sectional studies, and one was a randomized controlled trial. Five of these studies were carried out in developed countries, and they found no statistically significant difference in neurodevelopmental outcomes among twins and singletons. However, two of the three studies carried out in developing countries found a difference with singletons having significantly higher academic ratings than twins. Studies in which neurodevelopmental outcomes were measured early in life (1–5 years) showed no significant twin–singleton differences, while those in which it was measured later in life showed mixed twin–singleton differences. Overall, these studies may have been underpowered and may not have been optimally designed and implemented. There is need for studies with adequate sample sizes, good design, and optimal measurement of all relevant covariates in order to resolve the conflicting reports in the literature.
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影响因子：
6.1
作者：
Papiernik, Emile;Zeitlin, Jennifer;Draper, Elizabeth S.
通讯作者：
Draper, Elizabeth S.
影响因子：
3.8
作者：
Hjern, Anders;Ekeus, Cecilia;Lindblad, Frank
通讯作者：
Lindblad, Frank
DOI：
10.1016/j.ijgo.2006.11.002
发表时间：
2007-02-01
影响因子：
3.8
作者：
Acosta-Rojas, R.;Becker, J.;Gratacos, E.
通讯作者：
Gratacos, E.
DOI：
10.1375/1369052012452
发表时间：
2001-08-01
期刊：
Twin research : the official journal of the International Society for Twin Studies
影响因子：
--
作者：
Mosuro, A A;Agyapong, A N;Deen, S
通讯作者：
Deen, S
DOI：
10.1375/twin.4.6.431
发表时间：
2001-12-01
期刊：
Twin research : the official journal of the International Society for Twin Studies
影响因子：
--
作者：
Asztalos, E;Barrett, J F;Luther, M
通讯作者：
Luther, M