Systematic identification of tRNA genes in Drosophila melanogaster.

Systematic identification of tRNA genes in Drosophila melanogaster.
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DOI:
10.17912/micropub.biology.000560
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发表时间:
2022
影响因子:
--
通讯作者:
Lowe, Todd M
Lowe, Todd M
中科院分区:
其他
文献类型:
--
作者:
Marygold, Steven J;Chan, Patricia P;Lowe, Todd M

文献摘要

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转运RNA (tRNAs)是一种普遍存在的适配器分子,在蛋白质合成过程中将信使RNA (mRNA)中的特定密码子与其相应的氨基酸连接起来。果蝇的tRNA基因已经被研究了半个多世纪,但缺乏系统的鉴定和命名。在这里,我们回顾并整合了FlyBase和基因组tRNA数据库(GtRNAdb)中的数据,以确定黑腹龙核基因组和线粒体基因组中的tRNA基因的完整互补。我们应用一个逻辑和信息命名所有tRNA基因,并提供其特征和基因组特征的概述。
Transfer RNAs (tRNAs) are ubiquitous adapter molecules that link specific codons in messenger RNA (mRNA) with their corresponding amino acids during protein synthesis. The tRNA genes of Drosophila have been investigated for over half a century but have lacked systematic identification and nomenclature. Here, we review and integrate data within FlyBase and the Genomic tRNA Database (GtRNAdb) to identify the full complement of tRNA genes in the D. melanogaster nuclear and mitochondrial genomes. We apply a logical and informative nomenclature to all tRNA genes, and provide an overview of their characteristics and genomic features.