Left ventricular mass and myocardial scarring in women with hypertensive disorders of pregnancy.
Left ventricular mass and myocardial scarring in women with hypertensive disorders of pregnancy.
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妊娠期高血压疾病女性的左心室质量和心肌疤痕。
DOI：
10.1136/openhrt-2020-001273
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发表时间：
2020
期刊：
影响因子：
2.7
通讯作者：
BaireyMerz,Noel
中科院分区：
文献类型：
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作者：
Quesada,Odayme;Park,Ki;Wei,Janet;Handberg,Eileen;Shufelt,Chrisandra;Minissian,Margo;Cook-Wiens,Galen;Zarrini,Parham;Pacheco,Christine;Tamarappoo,Balaji;Thomson,LouiseEJ;Berman,DanielS;Pepine,CarlJ;BaireyMerz,Noel
妊娠期高血压疾病（HDP）可预测未来心血管事件。我们的目的是探讨HDP的历史和随后的高血压（HTN），心肌结构和功能，和晚期钆增强（LGE）scare.Methods和resultsWe之间的关系进行了评估的前瞻性队列的妇女怀疑缺血，没有阻塞性冠状动脉疾病（INOCA）进行应力/休息心脏磁共振成像（cMRI）与LGE在妇女的缺血综合征评估冠状动脉血管功能障碍的研究。在入组时收集自我报告的妊娠史和HDP（妊娠HTN、先兆子痫、毒血症和子痫）。在我们的346例队列中，20%的女性报告有HDP病史。HDP病史与HTN几率增加3.2倍相关。有HDP和HTN病史的女性与仅HDP的女性相比，cMRI测量的左心室（LV）质量更高（99.4±2.6 g vs 87.7±3.2 g，p=0.02）。虽然我们发现了类似的频率LGE疤痕，我们观察到的趋势增加LGE疤痕大小（5.1±3.4 g对8.0±3.4 g，p=0.09）的妇女与HDP的历史相比，妇女without.ConclusionIn一个高风险队列的妇女怀疑INOCA，20%的HDP的历史。有HDP病史的女性更容易患HTN。我们的研究表明HDP合并HTN的女性LV质量较高。尽管有和无HDP病史的女性中LGE瘢痕的存在没有差异，但我们观察到HDP女性中瘢痕尺寸更大的趋势。未来的研究需要在更大的女性队列中更好地评估HDP与心脏形态和LGE瘢痕形成的关系。
AimsHypertensive disorders of pregnancy (HDP) predict future cardiovascular events. We aim to investigate relations between HDP history and subsequent hypertension (HTN), myocardial structure and function, and late gadolinium enhancement (LGE) scar.Methods and resultsWe evaluated a prospective cohort of women with suspected ischaemia with no obstructive coronary artery disease (INOCA) who underwent stress/rest cardiac magnetic resonance imaging (cMRI) with LGE in the Women’s Ischemia Syndrome Evaluation-Coronary Vascular Dysfunction study. Self-reported history of pregnancy and HDP (gestational HTN, pre-eclampsia, toxaemia and eclampsia) were collected at enrollment. In our cohort of 346, 20% of women report a history of HDP. HDP history was associated with 3.2-fold increased odds of HTN. Women with a history ofbothHDP and HTN had higher cMRI measured left ventricular (LV) mass compared with women with HDP only (99.4±2.6 g vs 87.7±3.2 g, p=0.02). While we found a similar frequency of LGE scar, we observed a trend towards increased LGE scar size (5.1±3.4 g vs 8.0±3.4 g, p=0.09) among the women with HDP history compared to women without.ConclusionIn a high-risk cohort of women with suspected INOCA, 20% had a history of HDP. Women with HDP history were more likely to develop HTN. Our study demonstrates higher LV mass in women with HDP and concomitant HTN. Although the presence of LGE scar was not different in women with and without HDP history, we observed a trend towards larger scar size in women with HDP. Future studies are needed to better assess the relationship of HDP and cardiac morphology and LGE scarring in a larger cohort of women.