Plant polyphenols inhibit VacA, a toxin secreted by the gastric pathogen Helicobacter pylori
Plant polyphenols inhibit VacA, a toxin secreted by the gastric pathogen Helicobacter pylori
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DOI：
10.1016/s0014-5793(03)00443-5
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发表时间：
2003-05-22
期刊：
影响因子：
3.5
通讯作者：
Zoratti, M
中科院分区：
文献类型：
--
作者：
Tombola, F;Campello, S;Zoratti, M
VacA是广泛存在的胃内细菌幽门螺杆菌的主要毒力因子。它通过在血浆和内体膜中形成阴离子选择性、尿素渗透性通道而引起细胞空泡化和组织损伤。我们报告，几个黄酮衍生物和其他多酚类物质存在于蔬菜和植物抑制离子和尿素传导和细胞空泡化的VacA。红葡萄酒和绿色茶含有许多有问题的化合物，也能有效地抑制毒素。这些观察结果表明，多酚或多酚衍生物可能是有用的，在预防或治疗H。幽门相关性胃病(C)2003年由Elsevier Science B.V.代表欧洲生物化学学会联合会出版。
VacA is a major virulence factor of the widespread stomach-dwelling bacterium Helicobacter pylori. It causes cell vacuolation and tissue damage by forming anion-selective, urea-permeable channels in plasma and endosomal membranes. We report that several flavone derivatives and other polyphenols present in vegetables and plants inhibit ion and urea conduction and cell vacuolation by VacA. Red wine and green tea, which contain many of the compounds in question, also potently inhibit the toxin. These observations suggest that polyphenols or poly-phenol derivatives may be useful in the prevention or cure of H. pylori-associated gastric diseases. (C) 2003 Published by Elsevier Science B.V. on behalf of the Federation of European Biochemical Societies.