Impact of a single dose of the 7-valent pneumococcal conjugate vaccine on colonization
Impact of a single dose of the 7-valent pneumococcal conjugate vaccine on colonization
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DOI：
10.1016/j.vaccine.2010.02.070
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发表时间：
2010-04-26
期刊：
影响因子：
5.5
通讯作者：
de Lencastre, Herminia
中科院分区：
文献类型：
--
作者：
Frazao, Nelson;Sa-Leao, Raquel;de Lencastre, Herminia
大多数研究了7价肺炎球菌结合疫苗（PCV 7）对肺炎球菌植物群的影响，但未评价多重定殖和导致血清型替换的机制。这些问题在这里得到解决，同时评估一个单一的PCV 7剂量的影响一组儿童接受一个PCV 7剂量后，鼻咽采样，与对照组没有接受疫苗，两组再次采样一个月后，多达10个肺炎球菌分离株回收每个殖民儿童-1224分离株进行血清分型和代表性的特征，脉冲场凝胶电泳在接种疫苗的儿童。疫苗（VT）和非疫苗（NVT）类型之间的血清型替换发生在单一和多个载体中，并且VT不易于从头获得。仅在接种单剂疫苗后1个月在接种组中检测到NVT揭盲。PCV 7可预防VT新发获得并促进NVT暴露。(C)2010爱思唯尔有限公司版权所有
The impact of the 7-valent pneumococcal conjugate vaccine (PCV7) on the pneumococcal flora has been mostly studied without evaluating multiple colonization and the mechanism(s) leading to serotype replacement. These issues are addressed here, while assessing the effect of a single PCV7 dose A group of children received one PCV7 dose just after nasopharyngeal sampling, with the control receiving no vaccine and both groups being sampled again a month later Up to 10 pneumococcal isolates were recovered per colonized child-1224 isolates were serotyped and representative ones characterized by pulsed-field gel electrophoresis In vaccinated children. serotype replacement between vaccine (VT) and non-vaccine (NVT) types occurred in single and multiple carriers, and VTs were less prone to be de novo acquired. NVT unmasking was only detected in the vaccinated group One month after vaccination with a single dose. PCV7 prevents VT de novo acquisition and promotes NVT unmasking. (C) 2010 Elsevier Ltd All rights reserved