Prevalence of Cancer in Patients with Thyroid Nodules in the Island of Cyprus: Predictive Value of Ultrasound Features and Thyroid Autoimmune Status
Prevalence of Cancer in Patients with Thyroid Nodules in the Island of Cyprus: Predictive Value of Ultrasound Features and Thyroid Autoimmune Status
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DOI：
10.1159/000430438
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发表时间：
2015-01-01
影响因子：
4.7
通讯作者：
Economides, Panayiotis A.
中科院分区：
文献类型：
--
作者：
Hadjisavva, Irini S.;Dina, Roberto;Economides, Panayiotis A.
背景资料：本研究的目的是确定在塞浦路斯岛接受甲状腺结节超声引导细针穿刺活检（USgFNA）的患者中甲状腺癌的患病率。超声特征以及自身免疫性甲状腺疾病的存在被评估为恶性肿瘤的危险因素。研究方法：2007年7月至2009年7月期间，322名连续检查的患者（272名女性/50名男性，年龄13-81岁）在转诊内分泌诊所接受了甲状腺结节USgFNA。检查的超声特征包括：回声、边缘不规则、成分、钙化、血管增加和结节大小。记录是否存在自身免疫性甲状腺疾病。结果：在548个结节中，74个（13.6%）被分类为THY 3，4或5。75例患者（123个结节）接受了手术切除。46例（64个结节）经病理证实为甲状腺癌。可疑/恶性细胞学与实体成分、低回声、边缘不规则和钙化存在显著相关。抗甲状腺球蛋白抗体阳性（p < 0.05）和Graves病（p = 0.01）与可疑/恶性细胞学检查之间也存在显著相关性。结论：甲状腺癌的总患病率为14.3%。超声特征对甲状腺恶性肿瘤具有高度预测性。甲状腺自身免疫应被认为是一个危险因素。(C)2015年欧洲甲状腺协会发表的S。Karger AG，巴塞尔
Background: The purpose of this study was to determine the prevalence of thyroid carcinoma in patients who underwent ultrasound-guided fine needle aspiration biopsy (USgFNA) of thyroid nodules in the island of Cyprus. Ultrasound features as well as the presence of autoimmune thyroid disease were evaluated as risk factors for malignancy. Methods: 322 consecutively examined patients (272 females/50 males, age 13-81) underwent USgFNA of thyroid nodules in a referral endocrine clinic between July 2007 and July 2009. The ultrasonographic characteristics examined were: echogenicity, margin irregularity, composition, calcifications, presence of increased vasculature and nodule size. The presence or absence of autoimmune thyroid disease was recorded. Results: From the 548 nodules examined, 74 (13.6%) were classified as THY3, 4 or 5. 75 patients (123 nodules) underwent surgical resection. 46 patients (64 nodules) proved to have thyroid carcinoma by histology. There was a significant correlation of suspicious/malignant cytology with solid composition, hypoechogenicity, irregular margins and the presence of calcifications. A significant association was also noted between the presence of positive antithyroglobulin antibodies (p < 0.05) and Graves' disease (p = 0.01) with suspicious/malignant cytology. Conclusion: The overall prevalence of thyroid cancer was 14.3%. Ultrasound characteristics were highly predictive of thyroid malignancy. Thyroid autoimmunity should be considered as a risk factor. (C) 2015 European Thyroid Association Published by S. Karger AG, Basel