Patient reported outcome in HFpEF: Sex-specific differences in quality of life and association with outcome
Patient reported outcome in HFpEF: Sex-specific differences in quality of life and association with outcome
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DOI：
10.1016/j.ijcard.2018.04.102
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发表时间：
2018-09-15
影响因子：
3.5
通讯作者：
Lund, Lars H.
中科院分区：
文献类型：
--
作者：
Faxen, Ulrika Ljung;Hage, Camilla;Lund, Lars H.
背景：射血分数保留性心力衰竭（HFpEF）与生活质量（QoL）或患者报告结局（PRO）差相关。尽管女性在HFpEF中占主导地位，但PRO的性别特异性差异仍然研究甚少。方法和结果：在378例来自Karen研究的HFpEF患者中，评估了EQ-5D-3L（R）和明尼苏达心力衰竭生活问卷（R）（MLHFQ）。女性（n = 212，57%）和男性的特征和合并症基本相似。女性在EQ-5D-3L（R）（EQ-VAS）中表现出较差的QoL，与年龄和HF严重程度无关，平均值（SD）为57（20）vs. 61（19），p = 0.010。MLHFQ无差异，31（21）vs. 29（21），p = 0.269。Spearman与HF严重程度（NYHA分级）的相关性为女性MLHFQ r（s）0.37 vs.男性0.41，p均为
Background: Heart failure with preserved ejection fraction (HFpEF) is associated with poor quality of life (QoL), or patient reported outcome(PRO). Despite female predominance in HFpEF, sex-specific differences in PROs remain poorly studied. We assessed PRO measures and their association with HF-severity and outcome in HFpEF by sex.Methods and results: In 378 patients with HFpEF from the KaRen study, EQ-5D-3L (R) and Minnesota Living with Heart Failure Questionnaire (R) (MLHFQ) were assessed. Characteristics and comorbidities were largely similar in women (n = 212, 57%) and men. Women expressed worse QoL in EQ-5D-3L (R) (EQ-VAS), independent of age and HF-severity, mean (SD), 57 (20) vs. 61 (19), p = 0.010. There was no difference in MLHFQ, 31 (21) vs. 29 (21), p = 0.269.Spearman's correlations with HF-severity (NYHA-class) were for MLHFQ in women r(s) 0.37 vs. men 0.41, p for both