Sexual transmission and the natural history of human herpesvirus 8 infection
Sexual transmission and the natural history of human herpesvirus 8 infection
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DOI：
10.1056/nejm199804023381403
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发表时间：
1998-04-02
影响因子：
158.5
通讯作者：
Kedes, DH
中科院分区：
文献类型：
--
作者：
Martin, JN;Ganem, DE;Kedes, DH
背景虽然人类疱疹病毒8（HHV-8）已被怀疑是卡波西肉瘤的病原体，很少有人知道它的血清阳性率在人口中，其传播方式，和其自然history.Methods弗朗西斯科男子的财富研究，开始于1984年，是一项研究的人口为基础的样本的男子在一个地区的人类免疫缺陷病毒（HIV）感染的高发病率。我们研究了所有400名基线感染HIV的男性和400名未感染HIV的男性样本。基线血清样本检测HHV-8潜伏相关核抗原（抗LANA）抗体。除了抗LANA血清阳性的血清阳性率和危险因素外，我们还分析了卡波西肉瘤发展的时间。在593名男性中的223名中发现（37.6%）在过去五年中报告过任何同性恋活动，195名纯异性恋男性中没有一人，抗LANA血清阳性与性传播疾病史相关，并与男性性交伴侣的数量呈线性相关。在基线同时感染HIV和HHV-8的男性中，10年卡波西肉瘤的概率为49.6%，基线抗LANA血清阳性先于随后的卡波西肉瘤，并与随后的卡波西肉瘤独立相关，即使在调整后;结论HHV-8感染率在男同性恋者中较高，HHV-8与同性伴侣的数量相关，并且与卡波西肉瘤在时间上和独立地相关。这些观察结果进一步证明HHV-8在卡波西肉瘤中具有病原学极，并且在男性中通过性传播。(C)1998年马萨诸塞州医学会。
Background Although human herpesvirus 8 (HHV-8) has been suspected to be the etiologic agent of Kaposi's sarcoma, little is known about its seroprevalence in the population, its modes of transmission, and its natural history.Methods The San Francisco Men's Wealth Study, begun in 1984, is a study of a population-based sample of men in an area with a high incidence of human immunodeficiency virus (HIV) infection. We studied all 400 men infected at base line with HIV and a sample of 400 uninfected men, Base-line serum samples were assayed for antibodies to HHV-8 latency-associated nuclear antigen (anti-LANA). In addition to the seroprevalence and risk factors for anti-LANA seropositivity, we analyzed the time to the development of Kaposi's sarcoma.Results Anti-LANA antibodies were: found in 223 of 593 men (37.6 percent) who reported any homosexual activity in the previous five years and in none of 195 exclusively heterosexual men, Anti-LANA seropositivity correlated with a history of sexually transmitted diseases and had a linear association with the number of male sexual-intercourse partners. Among the men who were infected with both HIV and HHV-8 at base line, the 10-year probability of Kaposi's sarcoma was 49.6 percent, Base-line anti-LANA seropositivity preceded and was independently associated with subsequent Kaposi's sarcoma, even after adjustment; for CD4 cell counts and the number of homosexual partners.Conclusions The prevalence of HHV-8 infection is high among homosexual men, correlates with the number of homosexual partners, and is temporally and independently associated with Kaposi's sarcoma, These observations are further evidence that HHV-8 has an etiologic Pole in Kaposi's sarcoma and is sexually transmitted among men. (C) 1998 Massachusetts Medical Society.