Effects of acute alcohol consumption on executive cognitive functioning in naturalistic settings
Effects of acute alcohol consumption on executive cognitive functioning in naturalistic settings
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DOI：
10.1016/j.addbeh.2010.06.022
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发表时间：
2010-11-01
影响因子：
4.4
通讯作者：
Tobias-Webb, Juliette
中科院分区：
文献类型：
--
作者：
Lyvers, Michael;Tobias-Webb, Juliette
实验室研究表明，急性酒精中毒会破坏执行认知功能的神经心理学测试，如威斯康星州卡片分类测试（WCST）。然而，这些研究结果在社会环境中典型的自我调节酒精摄入量的普遍性可能受到质疑。在本研究中，86名年轻人被招募在澳大利亚的酒吧进行电脑版的WCST。参与者的血液酒精浓度（BAC）范围从0到0.15%。虽然自我报告的措施，典型的饮酒量，冲动，额叶相关的日常功能都相互关联，符合其他最近的研究结果，多元回归表明，这些措施并不能预测持续性错误（PE），也没有非持续性错误（NPE）的WCST，而BAC唯一预测PE，但没有NPE。结果与酒精对前额叶皮质功能的剂量依赖性选择性破坏一致。在BAC曲线的上升段和下降段测试的参与者之间的表现没有差异。酒精相关性持续行为可能反映了酒精诱导的前额叶皮层多巴胺释放的抑制作用。(C)2010爱思唯尔有限公司版权所有。
Laboratory studies have demonstrated that acute alcohol intoxication can disrupt performance on neuropsychological tests of executive cognitive functioning such as the Wisconsin Card Sorting Test (WCST). However, the generalizability of such findings to typical self-regulated alcohol intake in social settings can be questioned. In the present study, 86 young adults were recruited at Australian bars to perform a computer version of the WCST. Participants displayed blood alcohol concentrations (BACs) across a range from 0 to 0.15%. Although self-report measures of typical alcohol consumption, impulsivity, and frontal lobe related everyday functioning were all intercorrelated in line with other recent findings, multiple regression indicated that these measures did not predict perseverative errors (PE) nor non-perseverative errors (NPE) on the WCST, whereas BAC uniquely predicted PE but not NPE. The results were consistent with a dose-dependent selective disruption of prefrontal cortical functioning by alcohol. There were no differences in performance between participants tested on the ascending limb of the BAC curve and those tested on the descending limb. Alcohol-associated perseveration may reflect the inhibitory effect of alcohol-induced dopamine release in the prefrontal cortex. (C) 2010 Elsevier Ltd. All rights reserved.