INHIBITION OF CELL MOTILITY BY INTERFERON
INHIBITION OF CELL MOTILITY BY INTERFERON
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DOI：
10.1126/science.6154315
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发表时间：
1980-01-01
期刊：
影响因子：
56.9
通讯作者：
ZETTER, BR
中科院分区：
文献类型：
--
作者：
BROUTYBOYE, D;ZETTER, BR
发现源自人白细胞、人成纤维细胞和小鼠成纤维细胞的干扰素可抑制培养细胞的运动性。它抑制肿瘤诱导的毛细血管内皮细胞的运动以及其他细胞类型的自发迁移。给定干扰素制剂抑制给定细胞类型运动性的能力与其在该特定细胞类型中的抗病毒活性成比例。抗人白细胞干扰素的抗血清可中和该制剂的运动抑制活性和抗病毒活性。
Interferon derived from human leukocytes, human fibroblasts, and mouse fibroblasts was found to inhibit the motility of cultured cells. It inhibits the tumor-induced motility of capillary endothelial cells as well as the spontaneous migration of other cell types. The ability of a given preparation of interferon to inhibit the motility of a given cell type is proportional to its antiviral activity in that particular cell type. Antiserum to human leukocyte interferon neutralizes both the motility-inhibitory activity and the antiviral activity of this preparation.