Poly(N-isopropylacrylamide)-based comb-type grafted hydrogel with rapid response to blood glucose concentration change at physiological temperature
Poly(N-isopropylacrylamide)-based comb-type grafted hydrogel with rapid response to blood glucose concentration change at physiological temperature
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DOI：
10.1002/pat.1079
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发表时间：
2008-08
影响因子：
3.4
通讯作者：
Shi-Bo Zhang;L. Chu;Dan Xu;Jie Zhang;Xiao‐Jie Ju;Rui Xie
中科院分区：
文献类型：
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作者：
Shi-Bo Zhang;L. Chu;Dan Xu;Jie Zhang;Xiao‐Jie Ju;Rui Xie
成功开发出一种新型葡萄糖响应水凝胶，可在生理温度下快速响应血糖浓度变化。该聚合物水凝胶含有苯基硼酸（PBA）基团作为葡萄糖传感器和热响应性聚（N-异丙基丙烯酰胺）（PNIPAM）基团作为执行器。通过首次将接枝聚(N-异丙基丙烯酰胺-co-3-丙烯酰氨基苯基硼酸)[聚(NIPAM-co-AAPBA)]侧链引入到交联聚(NIPAM-co-AAPBA)网络上，显着提高了水凝胶对环境葡萄糖浓度变化的响应率。合成的梳型接枝聚(NIPAM-co-AAPBA)水凝胶表现出令人满意的平衡葡萄糖响应特性，并且在生理温度下对葡萄糖浓度变化的响应速度比普通型交联聚(NIPAM-co-AAPBA)水凝胶快得多。这种具有快速响应速度的葡萄糖响应水凝胶在开发葡萄糖响应传感器和自调节药物输送系统领域非常有吸引力。版权所有 © 2008 约翰·威利父子有限公司
A new type of glucose-responsive hydrogel with rapid response to blood glucose concentration change at physiological temperature has been successfully developed. The polymeric hydrogel contains phenylboronic acid (PBA) groups as glucose sensors and thermo-responsive poly (N-isopropylacrylamide) (PNIPAM) groups as actuators. The response rate of the hydrogel to environmental glucose concentration change was significantly enhanced by introducing grafted poly(N-isopropylacrylamide-co-3-acrylamidophenylboronic acid) [poly(NIPAM-co-AAPBA)] side chains onto crosslinked poly(NIPAM-co-AAPBA) networks for the first time. The synthesized comb-type grafted poly(NIPAM-co-AAPBA) hydrogels showed satisfactory equilibrium glucose-responsive properties, and exhibited much faster response rate to glucose concentration change than normal type crosslinked poly(NIPAM-co-AAPBA) hydrogels at physiological temperature. Such glucose-responsive hydrogels with rapid response rate are highly attractive in the fields of developing glucose-responsive sensors and self-regulated drug delivery systems. Copyright © 2008 John Wiley & Sons, Ltd.