Structured spheres generated by an in-fibre fluid instability
Structured spheres generated by an in-fibre fluid instability
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DOI：
10.1038/nature11215
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发表时间：
2012-07-26
期刊：
影响因子：
64.8
通讯作者：
Abouraddy, Ayman F.
中科院分区：
文献类型：
--
作者：
Kaufman, Joshua J.;Tao, Guangming;Abouraddy, Ayman F.
从药物输送(1，2)到化学和生物催化(3)和化妆品(4)，人们已经很好地确定了对各种尺寸、各种材料和许多不同结构的颗粒的有效制造途径的需求(5)。在这里，我们利用纤维生产的固有可扩展性(6)和纤维内平台-瑞利毛细不稳定性(7)来制造尺寸均匀、结构均匀的球形颗粒，尺寸范围特别广：从2 mm到20 nm。多材料纤维(8)的热处理可控制地引起不稳定性(9)，从而得到有序的、定向的三维乳状物(10)。纤维芯和包层分别对应于分散相和连续相，两者在冷却时都在原位冻结，之后在需要时释放颗粒。通过将各种结构和材料排列在纤维的宏观放大模型中，我们生产出复合的、有结构的球形颗粒，如核壳颗粒、两室“Janus”颗粒(11)和多节“沙滩球”颗粒。此外，生产具有高密度芯的纤维可以实现前所未有的并行化水平。原则上，10(8)个50纳米的核心可以嵌入到米长、直径1毫米的纤维中，这些纤维可以被诱导在整个长度上同时分解成大小均匀的结构化球体。
From drug delivery(1,2) to chemical and biological catalysis(3) and cosmetics(4), the need for efficient fabrication pathways for particles over a wide range of sizes, from a variety of materials, and in many different structures has been well established(5). Here we harness the inherent scalability of fibre production(6) and an in-fibre Plateau-Rayleigh capillary instability(7) for the fabrication of uniformly sized, structured spherical particles spanning an exceptionally wide range of sizes: from 2 mm down to 20 nm. Thermal processing of a multimaterial fibre(8) controllably induces the instability(9), resulting in a well-ordered, oriented emulsion(10) in three dimensions. The fibre core and cladding correspond to the dispersed and continuous phases, respectively, and are both frozen in situ on cooling, after which the particles are released when needed. By arranging a variety of structures and materials in a macroscopic scaled-up model of the fibre, we produce composite, structured, spherical particles, such as core-shell particles, two-compartment 'Janus' particles(11), and multi-sectioned 'beach ball' particles. Moreover, producing fibres with a high density of cores allows for an unprecedented level of parallelization. In principle, 10(8) 50-nm cores may be embedded in metres-long, 1-mm-diameter fibre, which can be induced to break up simultaneously throughout its length, into uniformly sized, structured spheres.