Sex Differences in Peripheral Artery Disease.
Sex Differences in Peripheral Artery Disease.
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DOI：
10.1161/circresaha.121.320702
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发表时间：
2022-02-18
影响因子：
20.1
通讯作者：
Hess CN
中科院分区：
文献类型：
--
作者：
Pabon M;Cheng S;Altin SE;Sethi SS;Nelson MD;Moreau KL;Hamburg N;Hess CN
外周动脉疾病（PAD）是一种普遍的疾病，具有很高的发病率和死亡率，在总人口中仍未得到充分的诊断和治疗。尽管与男性相比，女性的PAD患病率相似或更高，但传统和非传统风险因素与PAD的关联以及PAD的临床表现因性别而异，可能导致女性延迟或缺乏诊断。这种基于性别的PAD表现差异可能源于健康时血管底物的性别二态性以及对血管应激源反应的性别差异。尽管在诊断为PAD的患者中，有一些已证实的治疗方法可改善症状并降低缺血性心血管和肢体事件的风险，但在治疗和结果方面仍观察到重要的性别差异。我们概述了当前关于性别差异的流行病学、病理生理学、临床表现和PAD管理的知识。
Peripheral artery disease (PAD) is a prevalent condition that confers substantial morbidity and mortality and remains underdiagnosed as well as undertreated in the overall population. Although PAD prevalence is similar or higher in women compared to men, associations of traditional and non-traditional risk factors with PAD and clinical manifestations of PAD differ by sex and may contribute to delayed or lack of diagnosis in women. Such sex-based differences in the manifestation of PAD may arise from sexual dimorphism in the vascular substrate in health as well as sex variation in the responses to vascular stressors. Despite the availability of proven therapies for improving symptoms and reducing risk of ischemic cardiovascular and limb events among patients with diagnosed PAD, important sex differences in treatment and outcomes have been observed. We provide an overview of current knowledge regarding sex differences in the epidemiology, pathophysiology, clinical presentation, and management of PAD.
DOI：
10.1089/jwh.2018.7113
发表时间：
2019-09
期刊：
Journal of women's health (2002)
影响因子：
--
作者：
Manfredini R;Lamberti N;Manfredini F;Straudi S;Fabbian F;Rodriguez Borrego MA;Basaglia N;Carmona Torres JM;Lopez Soto PJ
通讯作者：
Lopez Soto PJ
影响因子：
2.1
作者：
Kitada K;Ohkita M;Matsumura Y
通讯作者：
Matsumura Y