Translational relevance of rodent models of hypothalamic-pituitary-adrenal function and stressors in adolescence.
Translational relevance of rodent models of hypothalamic-pituitary-adrenal function and stressors in adolescence.
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DOI：
10.1016/j.ynstr.2016.08.003
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发表时间：
2017-02
影响因子：
5
通讯作者：
Simone JJ
中科院分区：
文献类型：
--
作者：
McCormick CM;Green MR;Simone JJ
当暴露发生在涉及神经发育提高的敏感时期时，由环境应激源引起的糖皮质激素升高可能对大脑结构和功能产生编程影响。近年来，青春期作为另一个敏感的发展时期，在这一时期，青春期的过渡可能会增加对压力的脆弱性，因此受到越来越多的关注。人类和大鼠在身体和行为发育方面有相似之处，大鼠已被有效地用作青春期的动物模型，以及这一时期个体发育的独特可塑性。这篇评论的重点是大鼠作为下丘脑-垂体-肾上腺（HPA）功能和应激源在青春期的转化研究模型的好处和挑战，突出了重要的相似之处和青春期大鼠和人类之间的对比，我们审查的主要压力程序，用于调查HPA应激反应及其后果在青春期大鼠。我们的结论是，在青春期大鼠的研究中，更注重青春期的时间作为一个因素，可能会增加翻译的相关性的研究结果。
Elevations in glucocorticoids that result from environmental stressors can have programming effects on brain structure and function when the exposure occurs during sensitive periods that involve heightened neural development. In recent years, adolescence has gained increasing attention as another sensitive period of development, a period in which pubertal transitions may increase the vulnerability to stressors. There are similarities in physical and behavioural development between humans and rats, and rats have been used effectively as an animal model of adolescence and the unique plasticity of this period of ontogeny. This review focuses on benefits and challenges of rats as a model for translational research on hypothalamic-pituitary-adrenal (HPA) function and stressors in adolescence, highlighting important parallels and contrasts between adolescent rats and humans, and we review the main stress procedures that are used in investigating HPA stress responses and their consequences in adolescence in rats. We conclude that a greater focus on timing of puberty as a factor in research in adolescent rats may increase the translational relevance of the findings.