Hesperidin contributes to the vascular protective effects of orange juice: a randomized crossover study in healthy volunteers
Hesperidin contributes to the vascular protective effects of orange juice: a randomized crossover study in healthy volunteers
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DOI：
10.3945/ajcn.110.004945
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发表时间：
2011-01-01
影响因子：
7.1
通讯作者：
Mazur, Andrzej
中科院分区：
文献类型：
--
作者：
Morand, Christine;Dubray, Claude;Mazur, Andrzej
背景：虽然大量人类研究表明，某些富含多酚的食物对心血管疾病的几种中间标志物具有一致的影响，但仍不清楚它们的作用是否与多酚专门相关。目的：我们通过餐后和慢性干预研究，研究了橙汁及其主要黄酮类化合物橙皮苷对微血管反应性、血压和心血管风险生物标志物的影响。设计：24 名健康超重男性（50-65 岁）被纳入研究一项随机、对照、交叉研究。在这三个为期 4 周的时期中，志愿者每天饮用 500 mL 橙汁、500 mL 对照饮料加橙皮苷 (CDH) 或 500 mL 对照饮料加安慰剂 (CDP)。所有测量和血液采集均在 4 周治疗期前后禁食过夜的受试者中进行。餐后研究在每个实验期开始时进行。结果：饮用橙汁或 CDH 4 周后，舒张压 (DBP) 显着低于饮用 CDP 后 (P = 0.02)，而在禁食过夜后测量，微血管内皮相关反应性并未受到显着影响。然而，与 CDP 相比，橙汁和 CDH 摄入均显着改善餐后微血管内皮反应性（P
Background: Although numerous human studies have shown consistent effects of some polyphenol-rich foods on several intermediate markers for cardiovascular diseases, it is still unknown whether their action could be specifically related to polyphenols.Objective: We investigated the effect of orange juice and its major flavonoid, hesperidin, on microvascular reactivity, blood pressure, and cardiovascular risk biomarkers through both postprandial and chronic intervention studies.Design: Twenty-four healthy, overweight men (age 50-65 y) were included in a randomized, controlled, crossover study. Throughout the three 4-wk periods, volunteers daily consumed 500 mL orange juice, 500 mL control drink plus hesperidin (CDH), or 500 mL control drink plus placebo (CDP). All measurements and blood collections were performed in overnight-fasted subjects before and after the 4-wk treatment periods. The postprandial study was conducted at the beginning of each experimental period.Results: Diastolic blood pressure (DBP) was significantly lower after 4 wk consumption of orange juice or CDH than after consumption of CDP (P = 0.02), whereas microvascular endothelium-related reactivity was not significantly affected when measured after an overnight fast. However, both orange juice and CDH ingestion significantly improved postprandial microvascular endothelial reactivity compared with CDP (P