The Eµ-hnRNP K Murine Model of Lymphoma: Novel Insights into the Role of hnRNP K in B-Cell Malignancies.
The Eµ-hnRNP K Murine Model of Lymphoma: Novel Insights into the Role of hnRNP K in B-Cell Malignancies.
复制标题
Eµ-hnRNP - K小鼠淋巴瘤模型：hnRNP - K在b细胞恶性肿瘤中的作用的新见解。
DOI：
10.3389/fimmu.2021.634584
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发表时间：
2021
影响因子：
7.3
通讯作者：
Gallardo M
中科院分区：
文献类型：
--
作者：
Malaney P;Velasco-Estevez M;Aguilar-Garrido P;Aitken MJL;Chan LE;Zhang X;Post SM;Gallardo M
B细胞淋巴瘤是最具生物学和分子异质性的恶性肿瘤之一。这种癌症亚型固有的复杂性要求开发合适的动物模型系统来描述这种疾病的特征，最终目的是确定有效的治疗方法。在本文中，我们讨论了一种新的B细胞淋巴瘤的驱动因素--hnRNP K(异源核核糖核蛋白K)--一种RNA结合蛋白。我们介绍了Eµ-Hnrnpk小鼠模型，这是一种以B细胞中hnRNP K过度表达为特征的小鼠模型，它会发展为高外显性的B细胞淋巴瘤。在这个模型中发展的疾病的分子分析揭示了c-Myc癌基因通过转录后和翻译机制的上调，强调了非基因组MYC激活在B细胞淋巴瘤中的影响。最后，在E-Hnrnpk小鼠身上开发的疾病的可移植性使其成为评估新疗法的宝贵临床前平台。
B-cell lymphomas are one of the most biologically and molecularly heterogeneous group of malignancies. The inherent complexity of this cancer subtype necessitates the development of appropriate animal model systems to characterize the disease with the ultimate objective of identifying effective therapies. In this article, we discuss a new driver of B-cell lymphomas – hnRNP K (heterogenous nuclear ribonucleoprotein K)—an RNA-binding protein. We introduce the Eµ-Hnrnpk mouse model, a murine model characterized by hnRNP K overexpression in B cells, which develops B-cell lymphomas with high penetrance. Molecular analysis of the disease developed in this model reveals an upregulation of the c-Myc oncogene via post-transcriptional and translational mechanisms underscoring the impact of non-genomic MYC activation in B-cell lymphomas. Finally, the transplantability of the disease developed in Eµ-Hnrnpk mice makes it a valuable pre-clinical platform for the assessment of novel therapeutics.