Evaluation of the biocompatibility and mechanical properties of xenogeneic (porcine) extracellular matrix (ECM) scaffold for pelvic reconstruction
Evaluation of the biocompatibility and mechanical properties of xenogeneic (porcine) extracellular matrix (ECM) scaffold for pelvic reconstruction
复制标题
用于骨盆重建的异种（猪）细胞外基质（ECM）支架的生物相容性和机械性能评估
DOI：
10.1007/s00192-010-1288-9
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发表时间：
2011-02-01
影响因子：
1.8
通讯作者：
Liang, Zhiqing
中科院分区：
文献类型：
--
作者：
Liu, Lubin;Li, Deng;Liang, Zhiqing
异种（猪）细胞外基质（ECM）支架被认为是再生医学的理想生物材料;然而，从不同组织来源制备的ECM显示出不同的生物学特性。因此，全面了解不同组织来源的ECM的生物学特性，对于骨盆重建支架的设计至关重要。方法我们从组织学结构、吸水能力、生物降解能力、力学性能、抗菌活性、生物相容性和生物相容性等方面，比较了巴马小型猪不同组织来源的ECM作为骨盆生物补片的生物学特性，结果不同ECM支架结构差异明显，均具有良好的生物相容性，UBM具有较好的吸水能力（500%以上）、抗生物降解能力、机械性能、抗菌活性、结论猪UBM是一种理想的盆腔生物补片。
Introduction and hypothesisXenogeneic (porcine) extracellular matrix (ECM) scaffolds have been suggested as ideal biomaterials for regeneration medicine; however, ECM prepared from different tissue sources has shown distinctive biological properties. Therefore, a comprehensive understanding of biological characteristics of different tissue-derived ECM is essential in the design of scaffolds for pelvic reconstruction.MethodsWe compared the biological properties of ECM derived from different tissue sources of Bama miniature pigs as a pelvic biological patch in terms of histological structure, water absorption ability, biodegradation ability, mechanical properties, antimicrobial activity, and biocompatibility in vitro.ResultsDifferent ECM scaffolds have distinct structural differences, and all have good biocompatibility, and UBM exhibited better water uptake ability (above 500%), anti-biodegradation ability, mechanical properties, antimicrobial activity, and stem cell attachment properties than other tissue-derived ECM.ConclusionsPorcine UBM might serve as an ideal pelvic biological patch.