Stereological evaluation and Golgi study of the sexual dimorphisms in the volume, cell numbers, and cell size in the medial preoptic nucleus of the rat
Stereological evaluation and Golgi study of the sexual dimorphisms in the volume, cell numbers, and cell size in the medial preoptic nucleus of the rat
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大鼠内侧视前核体积、细胞数量和细胞大小两性二态性的体视学评估和高尔基体研究
DOI：
10.1023/a:1007076206828
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发表时间：
1999
期刊：
影响因子：
--
通讯作者：
M. Paula
中科院分区：
文献类型：
--
作者：
M. Madeira;S. Leal;M. Paula
内侧视前核（MPN）和视前区性二态性核（SDN-POA）是大鼠脑中突出的性二态性细胞群。然而，成年大鼠这些细胞核中性别相关差异的定量数据仅限于其体积。我们使用体视学方法和高尔基体浸渍材料来检查，在年轻成年大鼠中，MPN（包括其分裂）和 SDN-POA 体积的性别二态性是否反映了其神经元数量和大小的类似差异。我们发现，男性所有 MPN 分裂中的神经元总数均高于女性，平均体细胞体积也较大。此外，男性 MPN 神经元的树突总长度大于女性，但树突棘密度较小。同样，在 SDN-POA 中，男性的神经元总数和大小均大于女性。所有评估的定量参数的性别差异导致男性 MPN 和 SDN-POA 的体积相对于女性更大。此外，MPN 神经纤维的体积也表现出与性别相关的差异，并且这些差异与检测到的每个 MPN 分区的体积差异非常匹配。值得强调的是，在所有 MPN 分区和 SDN-POA 中，神经元的数量密度是唯一发现女性明显高于男性的参数。我们的结果表明，MPN 和 SDN-POA 在神经元的体积、总数以及神经元细胞体和树突树的大小方面表现出性别差异。此外，他们还表明，神经纤维对于 MPN 大小的性别二态性的建立至关重要。
The medial preoptic nucleus (MPN) and the sexually dimorphic nucleus of the preoptic area (SDN-POA) stand out as prominent sexually dimorphic cell groups of the rat brain. However, quantitative data on sex-related differences in these nuclei in the adult rat are confined to their volume. We have used stereological methods and Golgi-impregnated material to examine whether, in young adult rats, the sexual dimorphism in the volume of the MPN, including its divisions, and of the SDN-POA, reflect similar differences in the number and size of their neurons. We found that the total number of neurons in all MPN divisions is higher and the mean somatic volume larger in males than in females. In addition, the total dendritic length of MPN neurons is greater, but the dendritic spine density is smaller, in males than in females. Likewise, in the SDN-POA the total number and size of its neurons is greater in males than in females. The sex differences in all quantitative parameters evaluated accounted for the larger volume of the MPN and SDN-POA in males relative to females. In addition, the MPN neuropil also displays sex-related differences in its volume, and these differences closely match those detected for the volume of each MPN division. It deserves to be emphasised that the numerical density of neurons was the only parameter found to be significantly higher in females than in males in all MPN divisions and in the SDN-POA. Our results show that the MPN and the SDN-POA display sex differences in the volume, total number of neurons, and size of neuronal cell bodies and dendritic trees. Furthermore, they also indicate that the neuropil is critical for the establishment of sexual dimorphism in the size of the MPN.
雄性和雌性大鼠视前区性二形核分化的激素敏感期的终止。
DOI：
10.1016/0165-3806(90)90217-m
发表时间：
1990
期刊：
Brain research. Developmental brain research
影响因子：
--
作者：
Rhees,RW;Shryne,JE;Gorski,RA
通讯作者：
Gorski,RA