Chewing ameliorates the effects of restraint stress on pERK-immunoreactive neurons in the rat insular cortex
Chewing ameliorates the effects of restraint stress on pERK-immunoreactive neurons in the rat insular cortex
复制标题
咀嚼改善束缚应激对大鼠岛叶皮层 pERK 免疫反应神经元的影响
DOI：
10.1016/j.neulet.2018.03.008
复制
发表时间：
2018
影响因子：
2.5
通讯作者：
Toshitsugu Kawata
中科院分区：
文献类型：
--
作者：
Masami Onuki;Toshiharu Yamamoto;Kenichi Sasaguri;Kentaro Yamada;Naruo Okada;Toshitsugu Kawata
我们研究了咀嚼对前、后岛叶皮质在约束应激过程中的影响，使用磷酸化细胞外信号调节激酶（pERK）水平作为神经元反应的标志物。与对照组相比，仅应激组在前岛皮质和后岛皮质中均显示出增加的pERK免疫反应细胞数量（p <0.01）。在咀嚼应激组中，两个岛叶皮质中应激诱导的pERK免疫反应阳性细胞数量的增加被抑制，并且这些差异与仅应激组相比具有统计学显著性（p <0.01）。咀嚼对前岛叶皮层的抑制作用比后岛叶皮层更显著，前岛叶皮层参与情绪加工，后岛叶皮层参与感觉运动加工。因此，这些结果表明，咀嚼改善情绪和感觉运动的反应，在前，后岛叶皮层，分别与情绪形成过程比感觉运动过程的影响更大。
We investigated the effects of chewing on the anterior and posterior insular cortices during restraint stress using phosphorylated extracellular signal-regulated kinase (pERK) levels as a marker of neuronal responses. The stress only group demonstrated increased numbers of pERK-immunoreactive cells in both the anterior and posterior insular cortices compared to the control group (p <0.01). In the stress with chewing group, the stress-induced increase of pERK-immunoreactive cell numbers was suppressed in both insular cortices and these differences were statistically significant compared to the stress-only group (p <0.01). The suppressive effects of chewing were more prominent in the anterior insular cortex than in the posterior insular cortex.In general, the anterior insular cortex contributes to emotional processing, whereas the posterior insular cortex is associated with sensorimotor processes. Therefore, these results suggest that chewing ameliorates the emotional and sensorimotor responses to stress in the anterior and posterior insular cortices, respectively, with a greater effect on emotion-forming processes than on sensorimotor processes.