Tissue factor expression as a possible determinant of thromboembolism in ovarian cancer.
Tissue factor expression as a possible determinant of thromboembolism in ovarian cancer.
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组织因子表达是卵巢癌中血栓栓塞的可能决定因素。
DOI：
10.1038/sj.bjc.6603552
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发表时间：
2007-01-29
影响因子：
8.8
通讯作者：
Aonuma, K
中科院分区：
文献类型：
--
作者：
Uno, K;Homma, S;Satoh, T;Nakanishi, K;Abe, D;Matsumoto, K;Oki, A;Tsunoda, H;Yamaguchi, I;Nagasawa, T;Yoshikawa, H;Aonuma, K
卵巢癌，特别是透明细胞癌，据报道会增加静脉血栓栓塞（VTE）的风险。然而，其机制仍不清楚。组织因子（TF）被认为是癌细胞促凝血活性的主要因子。本研究检测了卵巢癌患者VTE中TF表达的参与情况。受试者包括32例连续患者（平均年龄49.8岁），组织学证实的卵巢癌。结合临床特征、D-二聚体水平和静脉超声检查检查VTE的存在。采用免疫组织化学分析将TF表达评估为4级。在32名患者中的10名（31%）中确定了静脉血栓栓塞，包括11名透明细胞癌患者中的5名。组织因子在24例透明细胞癌组织中的表达与VTE发生（P=0.0003）、D-二聚体浓度（P=0.003）和透明细胞癌（P<0.05）相关。多因素分析显示TF表达是VTE发生的独立预测因素（P<0.05）。组织因子（TF）表达可能是卵巢癌发生VTE的决定因素。特别是，透明细胞癌可能产生过量的TF，更有可能发展为VTE。
Ovarian cancer, and clear cell carcinoma in particular, reportedly increases the risk of venous thromboembolism (VTE). However, the mechanisms remain unclear. Tissue factor (TF) supposedly represents a major factor in the procoagulant activities of cancer cells. The present study examined the involvement of TF expression in VTE for patients with ovarian cancer. Subjects comprised 32 consecutive patients (mean age 49.8 years) with histologically confirmed ovarian cancer. Presence of VTE was examined using a combination of clinical features, D-dimer levels and venous ultrasonography. Immunohistochemical analysis was used to evaluate TF expression into 4 degrees. Venous thromboembolism was identified in 10 of the 32 patients (31%), including five of the 11 patients with clear cell carcinoma. Tissue factor expression was detected in cancer tissues from 24 patients and displayed significant correlations with VTE development (P=0.0003), D-dimer concentration (P=0.003) and clear cell carcinoma (P<0.05). Multivariate analysis identified TF expression as an independent predictive factor of VTE development (P<0.05). Tissue factor (TF) expression is a possible determinant of VTE development in ovarian cancer. In particular, clear cell carcinoma may produce excessive levels of TF and is more likely to develop VTE.