A cancer DNA phenotype in healthy prostates, conserved in tumors and adjacent normal cells, implies a relationship to carcinogenesis
A cancer DNA phenotype in healthy prostates, conserved in tumors and adjacent normal cells, implies a relationship to carcinogenesis
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DOI：
10.1073/pnas.0509630102
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发表时间：
2005-12-27
影响因子：
11.1
通讯作者：
Anderson, KM
中科院分区：
文献类型：
--
作者：
Malins, DC;Gilman, NK;Anderson, KM
在某些 55 岁以上健康男性的前列腺中发现了与肿瘤 DNA 结构相同的癌症 DNA 表型。我们现在表明，与肿瘤相邻的正常组织中也存在相同的 DNA 特征。这一发现意味着正常前列腺细胞从开始到肿瘤发展一直维持着表型。该表型在肿瘤、邻近正常细胞以及某些老年男性的正常前列腺细胞中的存在表明，它是肿瘤发展的潜在关键因素，并且可以作为癌症风险评估的早期生物标志物。抑制健康男性表型的发展或一旦形成就将其消除的干预措施可以抑制甚至预防肿瘤的形成。
A cancer DNA phenotype, identical to the DNA structure of tumors, has been identified in the prostate glands of certain healthy men over 55 years of age. We now show that the same DNA signature exists in normal tissues adjacent to tumors. This finding implies that the phenotype is maintained in normal prostate cells from its inception through tumor development. The presence of the phenotype in tumors, adjacent normal cells, and in the normal prostate cells of certain older men suggests that it is a potentially critical factor in tumor development and may serve as an early biomarker for cancer risk assessment. Intervention to inhibit the development of the phenotype in healthy men, or to eliminate it once formed, may suppress or even prevent tumor formation.