Vaginal Langerhans Cells Nonproductively Transporting HIV-1 Mediate Infection of T Cells
Vaginal Langerhans Cells Nonproductively Transporting HIV-1 Mediate Infection of T Cells
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DOI：
10.1128/jvi.05615-11
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发表时间：
2011-12-01
影响因子：
5.4
通讯作者：
Hladik, Florian
中科院分区：
文献类型：
--
作者：
Ballweber, Lamar;Robinson, Barry;Hladik, Florian
尽管其他模型表明，人类阴道中的朗格汉斯细胞(LCS)参与了传染性人类免疫缺陷病毒1型(HIV-1)的传播，但仍缺乏证据。在这里，我们展示了LC从暴露于HIV-1的阴道上皮细胞迁移，并将感染病毒传递给CD4(+)T细胞，而不是自身被生产性感染，我们指出了一条可能使HIV-1避免在阴道LC中降解的途径。迁移性LC以一种非生产性但有感染性的形式转运到当地淋巴管，可能有助于HIV-1逃避针对其细胞内生产生命周期的局部杀菌剂。
Although implied by other models, proof that Langerhans cells (LCs) in the human vagina participate in dissemination of infectious human immunodeficiency virus type 1 (HIV-1) has been lacking. Here, we show that LCs migrate from HIV-1-exposed vaginal epithelia and pass infectious virus to CD4(+) T cells without being productively infected themselves, and we point to a pathway that might enable HIV-1 to avoid degradation in vaginal LCs. Transport by migratory LCs to local lymphatics in a nonproductive but infectious form may aid HIV-1 in evasion of topical microbicides that target its intracellular productive life cycle.