Length Polymorphism in Heme Oxygenase-1 and Risk of CKD among Patients with Coronary Artery Disease
Length Polymorphism in Heme Oxygenase-1 and Risk of CKD among Patients with Coronary Artery Disease
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DOI：
10.1681/asn.2013111205
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发表时间：
2014-11-01
影响因子：
13.6
通讯作者：
Tarng, Der-Cherng
中科院分区：
文献类型：
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作者：
Chen, Yu-Hsin;Kuo, Ko-Lin;Tarng, Der-Cherng
在高危人群中，血红素加氧酶-1基因启动子上的鸟苷胸苷二核苷酸重复序列的长度多态与心血管事件和死亡率有关。实验数据表明，血红素加氧酶-1可以预防肾脏疾病。然而，在高危患者中，这种多态与慢性肾脏病的长期风险之间的关联尚不清楚。我们分析了1999年1月至2001年7月期间386例冠心病患者的血红素加氧酶-1基因启动子上鸟苷胸苷二核苷酸重复序列的等位基因频率。S等位基因代表短重复序列(=27)。主要的肾脏终点包括持续的血肌酐倍增和/或需要长期RRT的终末期肾病。次要终点是主要不良心血管事件和死亡率。研究结束时，肾脏终点L等位基因的调整危险比(95%可信区间)分别为1.99(1.27~3.14；P=0.003)、1.7(1.27~2.27；P
The length polymorphism of guanosine thymidine dinucleotide repeats in the heme oxygenase-1 gene promoter is associated with cardiovascular events and mortality in high-risk populations. Experimental data suggest that heme oxygenase-1 protects against kidney disease. However, the association between this polymorphism and long-term risk of CKD in high-risk patients is unknown. We analyzed the allelic frequencies of guanosine thymidine dinucleotide repeats in the heme oxygenase-1 gene promoter in 386 patients with coronary artery disease recruited from January 1999 to July 2001 and followed until August 31, 2012. The S allele represents short repeats (= 27). The primary renal end points consisted of sustained serum creatinine doubling and/or ESRD requiring long-term RRT. The secondary end points were major adverse cardiovascular events and mortality. At the end of study, the adjusted hazard ratios (95% confidence intervals) for each L allele in the additive model were 1.99 (1.27 to 3.14; P=0.003) for the renal end points, 1.70 (1.27 to 2.27; P