Breast Cancer and African Ancestry: Lessons Learned at the 10-Year Anniversary of the Ghana-Michigan Research Partnership and International Breast Registry.
Breast Cancer and African Ancestry: Lessons Learned at the 10-Year Anniversary of the Ghana-Michigan Research Partnership and International Breast Registry.
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DOI：
10.1200/jgo.2015.002881
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发表时间：
2016-10-01
影响因子：
--
通讯作者：
Awuah, Baffour
中科院分区：
文献类型：
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作者：
Jiagge, Evelyn;Oppong, Joseph Kwaku;Awuah, Baffour
西部、撒哈拉以南非洲和美国的非洲血统女性代表了一个群体子集，她们被诊断出患有生物侵袭性乳腺癌表型的风险增加，这些乳腺癌的雌激素受体、孕激素受体和 HER2/neu 标记均为阴性。这些肿瘤通常被称为三阴性乳腺癌。与种族或族裔身份相关的乳腺癌发病率和结果的差异促使国际乳腺登记处的建立，该登记处是在加纳库马西的 Komfo Anokye 教学医院、密歇根州安娜堡的密歇根大学综合癌症中心和密歇根州底特律的亨利·福特卫生系统之间的合作伙伴关系的基础上建立的。该研究合作项目的特色是教育培训计划以及与加纳非洲人、非裔美国人和白人/欧洲裔美国患者乳腺癌比较生物学相关的科学研究。目前，通过与姐妹网络（全国非裔美国乳腺癌幸存者组织）以及加纳（代表西非）和埃塞俄比亚（代表东非）的其他站点合作，国际乳腺登记处已扩大到涵盖美国各地的非裔美国患者。其活动目前通过亨利·福特卫生系统国际乳腺癌亚型研究中心进行协调。在此，我们回顾这一国际计划十周年的历史和成果。
Women with African ancestry in western, sub-Saharan Africa and in the United States represent a population subset facing an increased risk of being diagnosed with biologically aggressive phenotypes of breast cancer that are negative for the estrogen receptor, the progesterone receptor, and the HER2/neu marker. These tumors are commonly referred to as triple-negative breast cancer. Disparities in breast cancer incidence and outcome related to racial or ethnic identity motivated the establishment of the International Breast Registry, on the basis of partnerships between the Komfo Anokye Teaching Hospital in Kumasi, Ghana, the University of Michigan Comprehensive Cancer Center in Ann Arbor, Michigan, and the Henry Ford Health System in Detroit, Michigan. This research collaborative has featured educational training programs as well as scientific investigations related to the comparative biology of breast cancer in Ghanaian African, African American, and white/European American patients. Currently, the International Breast Registry has expanded to include African American patients throughout the United States by partnering with the Sisters Network (a national African American breast cancer survivors' organization) and additional sites in Ghana (representing West Africa) as well as Ethiopia (representing East Africa). Its activities are now coordinated through the Henry Ford Health System International Center for the Study of Breast Cancer Subtypes. Herein, we review the history and results of this international program at its 10-year anniversary.