Features of MHC and NK gene clusters
Features of MHC and NK gene clusters
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DOI：
10.1016/j.trim.2005.03.001
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发表时间：
2005-08-01
影响因子：
1.5
通讯作者：
Trowsdale, J
中科院分区：
文献类型：
--
作者：
Kelley, J;Trowsdale, J
当将免疫基因组与一般基因组进行比较时，与疾病相关的较高患病率是免疫基因作为一个组的唯一显著遗传特征。然而，一些遗传特征，如显着水平的多态性和基因复制，存在于免疫基因的子集，即主要组织相容性复合物（MHC）和自然杀伤（NK）细胞受体基因复合物。在这篇综述中，我们讨论了MHC和NK受体基因簇的特点，它们的上位相互作用，以及两者对疾病的影响。(C)2005 Elsevier B.V保留所有权利。
When comparing the immune genome to the genome in general, a higher prevalence for association with disease is the only genetic feature significant in immune genes as a group. However, some genetic features, such as marked levels of polymorphism and gene duplication, are present in subsets of immune genes, namely the Major Histocompatibility Complex (MHC) and Natural Killer (NK) cell receptor gene complexes. In this review, we discuss features of MHC and NK receptor gene clusters, their epistatic interactions, and the impact of both on association to disease. (C) 2005 Elsevier B.V All rights reserved.