Prognostic significance of B7-H4 expression in matched primary pancreatic cancer and liver metastases.
Prognostic significance of B7-H4 expression in matched primary pancreatic cancer and liver metastases.
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B7-H4 表达在匹配的原发性胰腺癌和肝转移中的预后意义
DOI：
10.18632/oncotarget.12665
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发表时间：
2016-11-01
期刊：
影响因子：
--
通讯作者：
Yao H
中科院分区：
文献类型：
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作者：
Qian Y;Sang Y;Wang FX;Hong B;Wang Q;Zhou X;Weng T;Wu Z;Zheng M;Zhang H;Yao H
胰腺癌患者发生肝转移是常见的，预后较差。转移组织中生物标志物分析的临床相关性是必要的。B7-H4对T细胞介导的反应有抑制作用，可能参与肿瘤的发生发展。虽然B7-H4在胰腺癌中表达，但其在胰腺癌肝转移灶中的表达尚不清楚。本研究采用免疫组化方法对43例胰腺癌肝转移（15/43例原发相匹配）和57例无肝转移或其他远处转移的胰腺癌进行B7-H4表达分析。采用生存曲线和log-rank检验检验B7-H4表达与生存的关系。B7-H4在43例肝转移中有28例（65.1%）高表达，在15例匹配的原发肿瘤中有9例（60.0%）高表达。B7-H4在肝转移灶中的表达明显高于匹配的原发灶（p < 0.05）。原发性胰腺癌中B7-H4高表达的患者发生肝转移的风险较高（p < 0.05）。单因素分析中，B7-H4表达与死亡风险显著相关（p < 0.05）。多因素分析表明B7-H4是独立的预后指标（p < 0.05）。我们的研究结果显示B7-H4与胰腺癌肝转移患者预后不良有关。B7-H4可能促进胰腺癌转移，有望成为胰腺癌的潜在预后指标。
Liver metastasis development in pancreatic cancer patients is common and confers a poor prognosis. Clinical relevance of biomarker analysis in metastatic tissue is necessary. B7-H4 has an inhibitory effect on T cell mediated response and may be involved in tumor development. Although B7-H4 expression has been detected in pancreatic cancer, its expression in liver metastases from pancreatic cancer is still unknown. In this study, overall 43 pancreatic cancer liver metastases (with matched primaries in 15/43 cases) and 57 pancreatic cancer cases without liver metastases or other distant metastases were analyzed for their expression of B7-H4 by immunohistochemistry. Survival curves and log-rank tests were used to test the association of B7-H4 expression with survival. B7-H4 was highly expressed in 28 (65.1%) of the 43 liver metastases and 9 (60.0%) of the 15 matched primary tumors. The expression of B7-H4 in liver metastases was significantly higher than in the matched primary tumors (p < 0.05). Patients with high B7-H4 expression in their primary pancreatic cancer had higher risk of developing liver metastases (p < 0.05). In univariate analysis, B7-H4 expression was significantly associated with the risk of death (p < 0.05). And the multivariate analysis identified that B7-H4 was an independent prognostic indicator (p < 0.05). Our results revealed B7-H4 to be associated with poor prognosis in patients with pancreatic cancer liver metastasis. B7-H4 may promote pancreatic cancer metastasis and was promising to be a potential prognostic indicator of pancreatic cancer.