HOMOCYSTEINE AND MYOCARDIAL-INFARCTION
HOMOCYSTEINE AND MYOCARDIAL-INFARCTION
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DOI：
10.1016/0021-9150(88)90147-5
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发表时间：
1988-06-01
期刊：
影响因子：
5.3
通讯作者：
HULTBERG, BL
中科院分区：
文献类型：
--
作者：
ISRAELSSON, B;BRATTSTROM, LE;HULTBERG, BL
一组21名男性中的5名（24%）受试者，年龄48-58岁（平均54岁），在55岁之前遭受首次心肌梗死（MI），并且在MI之前的健康筛查中相对维斯常规风险因素具有低风险特征，在MI后1-7年（平均3年）内进行研究时，空腹状态下血浆总同型半胱氨酸值异常高。患者组与36名对照组受试者在性别、年龄、舒张压、吸烟、血清胆固醇和甘油三酯浓度方面完全匹配。总血浆同型半胱氨酸呈负相关，红细胞叶酸和血清维生素B12，维生素浓度低于正态分布的中位数被发现在五个血浆同型半胱氨酸含量高，表明可能参与减少血浆同型半胱氨酸的蛋氨酸的再甲基化。甲硫氨酸负荷后，3例患者组（14%）的同型半胱氨酸水平超过对照组的平均值± 2 SD，这可能表明同型胱氨酸尿症的杂合性。结果与高血浆同型半胱氨酸含量可能是MI的危险因素的假设是一致的。
Five (24%) subjects out of a group of 21 men, 48-58 years old (mean 54), who had suffered their first myocardial infarction (MI) before the age of 55 and with a low risk profile vis-a-vis conventional risk factors in a health screening preceding the MI, had abnormally high total plasma homocysteine values in the fasting state when investigated within 1-7 years (mean 3) after their MI. The patient group was exactly matched with 36 control subjects for sex, age, diastolic blood pressure, smoking, and serum concentrations of cholesterol and triglycerides. Total plasma homocysteine was negatively correlated to both erythrocyte folate and serum vitamin B12, and vitamin concentrations below the median of the normal distribution were found in the five with high plasma homocysteine content, indicating a possible involvement of reduced remethylation of plasma homocysteine to methionine. After methionine loading, in 3 of the patient group (14%) homocysteine levels exceeded mean + 2 SD for controls, which may indicate heterozygosity for homocystinuria. Results are consistent with the hypothesis that a high plasma homocysteine content may be a risk factor for MI.