Interferon‐beta, MCNU, and conventional radiotherapy for pediatric patients with brainstem glioma
Interferon‐beta, MCNU, and conventional radiotherapy for pediatric patients with brainstem glioma
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DOI：
10.1002/pbc.21987
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发表时间：
2009-07
影响因子：
3.2
通讯作者：
Masasuke Ohno;A. Natsume;M. Fujii;Motokazu Ito;T. Wakabayashi
中科院分区：
文献类型：
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作者：
Masasuke Ohno;A. Natsume;M. Fujii;Motokazu Ito;T. Wakabayashi
大多数脑干胶质瘤患儿在确诊后2年内死亡，患者的中位生存时间不到1年。化疗在儿童脑干胶质瘤治疗中的作用尚未明确。本研究的主要目的是评价干扰素-β（IFN-β）、雷莫司汀（MCNU）和放疗（IMR疗法）对在本机构接受治疗的脑干胶质瘤患者的治疗效果。我们还通过评估血清DNA中O 6-甲基鸟嘌呤-DNA甲基转移酶（MGMT）启动子甲基化来确定患者对IMR治疗的反应。
Most children with brainstem glioma die within 2 years of diagnosis, and the median survival time for patients with this condition is less than 1 year. The role of chemotherapy in the treatment of children with brainstem glioma is not well defined. The primary aim of this study is to evaluate the effects of treatment with interferon‐β (IFN‐β), ranimustine (MCNU), and radiotherapy (IMR therapy) administered to brainstem glioma patients treated at our institution. We also determined patient response to IMR therapy by evaluating O6‐methylguanine‐DNA methyltransferase (MGMT) promoter methylation in serum DNA.