VA COOPERATIVE STUDY ON ALCOHOLIC HEPATITIS-II - PROGNOSTIC-SIGNIFICANCE OF PROTEIN-CALORIE MALNUTRITION
VA COOPERATIVE STUDY ON ALCOHOLIC HEPATITIS-II - PROGNOSTIC-SIGNIFICANCE OF PROTEIN-CALORIE MALNUTRITION
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DOI：
10.1093/ajcn/43.2.213
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发表时间：
1986-02-01
影响因子：
7.1
通讯作者：
RABIN, L
中科院分区：
文献类型：
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作者：
MENDENHALL, CL;TOSCH, T;RABIN, L
对352例酒精性肝炎患者进行了蛋白质热量营养不良的评估。为了便于营养状况的数据分析，使用8个营养参数为每个患者计算了PCM评分。PCM评分与死亡率、肝病临床严重程度和生化肝功能障碍显著相关。当30天PCM评分的变化与30天卡路里摄入量(以基础能量消耗(BEE)百分比表示)进行比较时，观察到轻微显著的相关性(p=0.05)。然而，那些在住院30天以上PCM评分有所改善的患者也提高了他们的6个月和1年生存率。这些数据表明，由PCM评分决定的营养状况对预后有重要意义。还需要更多的研究来确定积极的蛋白质-卡路里营养疗法在酒精性肝炎管理中的有益作用。
Three hundred and fifty-two patietns with alcoholic hepatitis were evaluted for protein-calorie malnutrition (PCM). In order to facilitate data analysis of nutritional status, a PCM score was calculated for each patient using eight nutritional parameters. The PCM score correlated significantly with mortality, clinical severity of the liver disease, and biochemical liver dysfunction. When 30 day changes in the PCM scores were compared with 30 day caloric intake (expressed as percent basal energy expenditure (BEE)), a marginally significant correlation was observed (p = 0.05). However, those patients who showed improvement in their PCM score over 30 days of hospitalization also improved their 6-mo and 1-yr survival. These data indicate that nutrition, as determined by the PCM score, has prognostic significance. Additional studies are needed to establish the beneficial role for vigorous protein-calorie nutritional therapy in the management of alcoholic hepatitis.